Modelling metabolic systems

• US 20050071141A1
• Filed: 09/06/2002
• Published: 03/31/2005
• Est. Priority Date: 09/06/2001
• Status: Abandoned Application

• Current Assignee: Univation Limited
• Original Assignee: Univation Limited
• Inventors: Butler, Richard
• Application Number:
  US10/488,907
• Publication Number:
  US 20050071141A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

A method of modelling a metabolic function of an individual is described, wherein a first (10A) and second (10B) set of data are input into a database (12). The first set of data (10A) may constitute information of the diet of an individual, whereas the second set of data (10B) may constitute information on the individual'"'"'s activity. “Other” data (10C) may also be input into the database (12). A third set of data relating to hormone activity within the body is also included. A modelling region (20) employs a plurality of mathematical models in order to provide an output function (30, 31) indicative of the time variation of a metabolic function of the individual.

Claims

1. A method of calculating the time variation of a metabolic parameter of an individual, the method comprising the steps of:

(a) Inputting data into a database, the data including diet data relating to the diet of the individual and activity data relating to the activity of the individual, and personal data of the individual constituting one or more of date of birth, sex, height, or weight;

(b) Providing hormone interaction parameters relating to activity of one or more hormones;

(c) Calculating using a plurality of mathematical models, the time variation of a metabolic parameter, wherein the mathematical models utilize the hormone interaction parameters in conjunction with the diet data and/or the activity data, and model the energy stores, being the blood glucose, liver reserves, fat reserves, and muscle glycogen reserves of the body of the individual in calculating the time variation of a metabolic parameter.

2. The method as claimed in claim 1, wherein the step of calculating the time variation of the metabolic parameter includes determining which of the energy stores are used to meet energy demands from the state of the energy stores.

3. The method as claimed in claim 1, wherein the step of calculating the time variation of the metabolic parameter models the liver action of the individual, as determined by blood insulin level, blood glucose level, food input from the gut and status of the liver reserves.

4. The method as claimed in claim 1, wherein the hormone interaction parameters comprises a set of default parameters relating to the interaction of the one or more hormones with the individual.

5. The method as claimed in claim 4, wherein the hormone interaction parameters comprise one or more of the following user-dependent parameters:

an insulin activity delay parameter, an insulin sensitivity parameter, an insulin elimination rate parameter, an insulin production parameter.

6. The method as claimed in claim 1 comprising the additional step of inputting or importing measurement data relating to the measurement of a variable in a metabolic system.

7. The method as claimed in claim 6, comprising the step of comparing the measurement data with calculated values of the metabolic parameter.

8. A The method as claimed in claim 7, wherein the step of comparing comprises the sub-step of calculating of an error function said error function being defined as the difference in the measurement data values and the calculated metabolic parameter values over time.

9. The method as claimed in claim 8, comprising the additional steps of modifying at least one of the default parameters included in the hormone interaction parameters, recalculating the time variation of the metabolic parameter using the modified parameter, and recalculating the error function.

10. The method as claimed in claim 9, wherein the additional steps of modifying at least one of the default parameters included in the hormone interaction parameters, recalculating the time variation of the metabolic parameter using the modified parameter and recalculating the error function are reiterated in order to minimize the error.

11. The method as claimed in claim 1, wherein the data is the blood glucose level.

12. The method as claimed in claim 1, wherein the hormone is insulin.

13. The method as claimed in claim 1 comprising the step of entering into the database data relating to insulin doses taken by the individual.

14. The method as claimed in claim 1 comprising the additional steps of selecting food items from a table of food items specifying a quantity of each food item, and determining the nutritional composition of food consumed.

15. The method as claimed in claim 14 comprising the additional step of calculating a plurality of time courses corresponding to the time variation of fat, protein, and carbohydrates input into the metabolic system.

16. The method as claimed in claim 1, wherein the input of activity data includes the sub-steps of selecting an activity from a table of activities, and specifying a start time and duration of the activity.

17. The method as claimed in claim 16 comprising the step of determining the calories consumed by the individual user during the activity from the activity data a basal metabolic rate determined from the birth date, sex, height, and weight of the individual and a basal metabolic rate multiplying factor associated with the activity.

18. The method as claimed in claim 1, wherein the metabolic parameter is selected from the group comprising:

insulin levels in the blood, input of glucose from diet, input of fat, liver glucose reserves, fat reserves, muscle reserves, glucose output due to activity, rate of change of urine glucose, glucose used by the central nervous system, modelled blood glucose, and blood glucose error.

19. The method as claimed in claim 1, comprising the step of displaying calculated values to a user.

20. A method for calculating the effect of a change in diet, activity or insulin dose taken on the time variation of a metabolic parameter of an individual, the method comprising the steps of:

a) Calculating the time variation of a metabolic parameter;

b) Inputting data corresponding to a planned or retrospective change in diet, activity or insulin dose into a database;

c) Calculating, using a plurality of mathematical models, the time variation of a metabolic parameter, wherein the mathematical models utilize the hormone interaction parameters in conjunction with the data corresponding to a planned or retrospective change in diet, activity or insulin dose taken and model the blood glucose levels, liver reserves, fat reserves, and muscle glycogen reserves of the body of the individual in calculating the time variation of a metabolic parameter for the planned or retrospective change in diet or activity, or insulin dose taken.

21. The method as claimed in claim 20 comprising the additional step of displaying values of the metabolic parameter to a user.

22. The method as claimed in claim 20 comprising the additional step of comparing the time variation of the metabolic parameter with the time variation of a metabolic parameter for a planned or retrospective change in diet, activity, or insulin dose, in order to provide information on the difference effected by the planned or retrospective change in diet, activity or insulin dose taken.

23. The method as claimed in claim 20, wherein the method is executed by a computer program.

24. A computer program adapted to execute the method claimed in claim 20.