Radiopharmaceutical formulations
First Claim
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1. A kit for preparing a radiopharmaceutical, the kit comprising a predetermined quantity of a complexing ligand and a predetermined quantity of an oxidant. wherein the radiopharmaceutical has a radiochemical purity of greater than 90% at about six hours after reconstitution.
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Abstract
A method is described for inhibiting the degradation of a diagnostic or radiotherapeutic radiopharmaceutical, especially radiolabeled compounds containing reducible moieties, by including oxidants either as a part of the composition for the preparation of such radiopharmaceuticals, or by adding an oxidant to such compositions immediately after the preparation of such radiopharmaceuticals.
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Citations
71 Claims
- 1. A kit for preparing a radiopharmaceutical, the kit comprising a predetermined quantity of a complexing ligand and a predetermined quantity of an oxidant. wherein the radiopharmaceutical has a radiochemical purity of greater than 90% at about six hours after reconstitution.
- 17. A kit for the preparation of a radiopiharmaceutical, the kit comprising a lyophilized composition comprising a predetermined quantity of a complexing ligand and a predetermined quantity of an oxidant, wherein the oxidant has the following structure:
- 32. A kit for the preparation of a radiopharmaceutical, the kit comprising a predetermined quantity of a complexing ligand of Formula II:
- 44. A pharmaceutical composition comprisinig a radiopharmaceutical and an oxidant, wherein the radiopharmaceutical has a radiochemical purity of greater than 90% at about six hours after reconstitution.
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56. A method of making a radiopharmaceutical composition, comprising the steps of:
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a) contacting a complexing ligand with a radionuclide to form a complex; and
b) contacting the complexing ligand with an oxidant, wherein the radiopharmaceutical composition has a radiochemical purity of greater than about 90% at about six hours after reconstitution. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification