PVP and PVA as in vivo biocompatible acoustic coupling medium

• US 20050074407A1
• Filed: 09/27/2004
• Published: 04/07/2005
• Est. Priority Date: 10/01/2003
• Status: Abandoned Application

• Current Assignee: Illinois Tool Works Inc.
• Original Assignee: Sonotech, Inc.
• Inventors: Smith, Larry L.
• Application Number:
  US10/951,220
• Publication Number:
  US 20050074407A1
• Time in Patent Office: Days
• US Class Current: 424/9.500
• CPC Class Codes: A61K 49/222 characterised by a special physical form, e.g. emulsions, liposomes

Abstract

An vivo biocompatible and bio-excretable lubricant and ultrasound coupling fluid or gel comprising polyvinylpyrrolidone (PVP) and/or polyvinyl alcohol (PVA). The inventive couplant fluid or gel comprises polyvinylpyrrolidone and/or polyvinyl alcohol solutions in water to which humectants such as alkylene glycols and/or polyalkylene glycols are added to achieve desired tactile and drying characteristics. Additionally, such fluids and gels may be prepared by addition of organic and inorganic cross-linkers.

Claims

1. An in vivo biocompatible ultrasound acoustic couplant or lubricant comprising:

at least one of 3-30 wt. % polyvinylpyrrolidone and 6-25 wt. % polyvinyl alcohol;

at least one of (alkylene glycol, polyalkylene glycol, and fats and esters thereof in an amount of 1-80 wt. %; and

,

the balance water.

2. The couplant or lubricant of claim 1 wherein said at least one of (alkylene glycol, polyalkylene glycol, and fats and esters thereof is included in an amount of 10-70 wt. %.

3. The couplant or lubricant of claim 1 wherein said at least one of (alkylene glycol, polyalkylene glycol, and fats and esters thereof is included in an amount of 20-60 wt. %.

4. The couplant or lubricant of claim 1 wherein the molecular weight of polyvinylpyrrolidone is in the range of 360,000-1,500,000 daltons.

5. The couplant or lubricant of claim 1 wherein polyvinylpyrrolidone is included in an amount of 10-20 wt. %.

6. The couplant or lubricant of claim 1 wherein polyvinylpyrrolidone is included in an amount of 10-12 wt. %.

7. The couplant or lubricant of claim 1 wherein polyvinyl alcohol is included in an amount of 9-15 wt. %.

8. The couplant or lubricant of claim 1 wherein said alkylene glycol comprises propylene glycol.

9. The couplant or lubricant of claim 1 wherein said polyalkylene glycol comprises polyethylene glycol.

10. The couplant or lubricant of claim 1 wherein the polyethylene glycol has a molecular weight of 300.

11. The couplant or lubricant of claim 1 wherein said at least one of (alkylene glycol, polyalkylene glycol, and fats and esters thereof comprises two or more carbon atoms.

12. The couplant or lubricant of claim 11 wherein said at least one of (alkylene glycol, polyalkylene glycol, and fats and esters thereof comprises 2-6 carbon atoms.

13. The couplant or lubricant of claim 1 comprising:

15 wt. % polyvinyl alcohol;

20 wt. % propylene glycol; and

,

the balance water.

14. The couplant or lubricant of claim 1 comprising:

12 wt. % polyvinylpyrrolidone;

55 wt. % propylene glycol;

5 wt. % polyethylene glycol;

the balance water.

15. The couplant or lubricant of claim 1 comprising:

10 wt. % polyvinylpyrrolidone;

55 wt. % propylene glycol;

5 wt. % polyethylene glycol;

the balance water.

16. The couplant or lubricant of claim 1 comprising:

9 wt. % polyvinyl alcohol

3 wt. % polyvinylpyrrolidone;

20 wt. % propylene glycol;

the balance water.

17. The couplant or lubricant of claim 1 being non cross-linked.

18. The couplant or lubricant of claim 1 being sterilized.

19. The couplant or lubricant of claim 1 being in the form of a liquid or gel.

20. The couplant or lubricant of claim 1 wherein said water is pyrogen free water.

21. The couplant or lubricant of claim 1 wherein the molecular weight of polyvinylpyrrolidone is in the range of 40,000-54,000 daltons.