Novel gene upregulated in cancers of the prostate

• US 20050074807A1
• Filed: 10/05/2004
• Published: 04/07/2005
• Est. Priority Date: 10/28/1999
• Status: Abandoned Application

• Current Assignee: Agensys, Inc. (Astellas Pharma Incorporated)
• Original Assignee: Agensys, Inc. (Astellas Pharma Incorporated)
• Inventors: Raitano, Arthur B., Mitchell, Steven Chappell, Jakobovits, Aya, Hubert, Rene S., Afar, Daniel E.H.
• Application Number:
  US10/959,697
• Publication Number:
  US 20050074807A1
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C12N 2799/026 where the vector is derived from a baculovirus
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.

Claims

1. A polypeptide comprising SEQ ID NO:

2.

2. The polypeptide of claim 1, wherein the polypeptide is encoded by a polynucleotide that is 90% identical to SEQ ID NO:

1.

3. The polypeptide of claim 1, wherein the polypeptide is encoded by SEQ ID NO:

1.

4. The polypeptide of claim 1, wherein the polypeptide is expressed from an expression vector.

5. The polypeptide of claim 4, wherein the expression vector encodes a coding sequence that is at least 90% identical to SEQ ID NO:

1.

6. The polypeptide of claim 1, wherein the polypeptide is expressed by a host cell.

7. The polypeptide of claim 6, wherein the host cell comprises an expression vector which encodes a coding sequence that is at least 90% identical to SEQ ID NO:

1.

8. The polypeptide of claim 6, wherein the host cell comprises an expression vector which encodes a coding sequence that is SEQ ID NO:

1.

9. A method of expressing a polypeptide, comprising:

providing a host cell which comprises an expression vector encoding a polynucleotide sequence which encodes the polypeptide of SEQ ID NO;

2; and

culturing the host cell under conditions wherein the polypeptide is expressed.

10. The method of claim 9, wherein the polynucleotide is at least 90% identical to SEQ ID NO:

1.

11. The method of claim 9, wherein the polynucleotide is SEQ ID NO:

1.

12. The method of claim 9, further comprising recovering the polypeptide.

13. The method of claim 9, wherein the host cell is a eucaryotic cell.

14. The method of claim 13, wherein the eucaryotic cell is a Chinese Hamster Ovary cell.

15. The method of claim 13, wherein the eucaryotic cell is a yeast cell.

16. The method of claim 13, wherein the eucaryotic cell is a plant cell.

17. The method of claim 9, wherein the host cell is a prokaryotic cell.

18. The method of claim 17, wherein the prokaryotic cell is a bacterial cell.

19. The method of claim 18, wherein the bacterial cell is an E. coli cell.

20. An immunogenic composition comprising a polypeptide of SEQ ID NO:

2.