Delivery of opioids through an inhalation route
First Claim
1. A method of treating pain or alcohol abuse, providing opioid reversal, or maintaining opioid addicts comprising administering a therapeutic amount of an opioid condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% opioid drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
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Abstract
The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin coating of an opioid composition and b) a device for dispensing said thin coating as a condensation aerosol.
120 Citations
29 Claims
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1. A method of treating pain or alcohol abuse, providing opioid reversal, or maintaining opioid addicts comprising administering a therapeutic amount of an opioid condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% opioid drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating pain or alcohol abuse, providing opioid reversal, or maintaining opioid addicts comprising administering a therapeutic amount of a fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of administering an opioid to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of an opioid having less than 5% opioid drug degradation products and an MMAD less than 3 microns wherein the peak plasma concentration of the opioid is achieved in less than 0.1 hours.
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20. A method of administering of fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil having less than 5% of fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration of fentanyl, naltrexone, buprenorphine, naloxone, butorphanol, hydromorphone, oxycodone, methadone, remifentanil, or sufentanil is achieved in less than 0.1 hours.
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21. A kit for delivering a drug aerosol comprising:
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a) a thin coating of an opioid composition and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification