Purine nucleoside analogues for treating Flaviviridae including hepatitis C
First Claim
1. A method of treating a host infected with a flavivirus or pestivirus, comprising administering an effective amount of an anti-pestivirus or anti-flavivirus biologically active ribofuranonucleoside of Formula (I):
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Abstract
This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.
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Citations
67 Claims
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1. A method of treating a host infected with a flavivirus or pestivirus, comprising administering an effective amount of an anti-pestivirus or anti-flavivirus biologically active ribofuranonucleoside of Formula (I):
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2. A method of treating a host infected with a flavivirus or pestivirus, comprising administering an effective amount of an anti-pestivirus or anti-flavivirus biologically active ribofuranonucleoside of Formula (II):
- 3. A method of treating a host infected with a flavivirus or pestivirus, comprising administering an effective amount of an anti-pestivirus or anti-flavivirus biologically active ribofuranonucleoside of Formula (III):
- 12. A method of treating a host infected with a flavivirus or pestivirus, comprising administering an effective amount of an anti-pestivirus or anti-flavivirus biologically active ribofuranonucleoside of Formula (IV):
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35. A compound of the general structure of Formula (I):
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36. A compound of the general structure of Formula (II):
- 37. A compound of the general structure of Formula (III):
- 46. A compound of the general structure of Formula (IV):
Specification