System and method for in vivo sensing

• US 20050075555A1
• Filed: 05/26/2004
• Published: 04/07/2005
• Est. Priority Date: 05/09/2002
• Status: Abandoned Application

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Palti, Yoram, Glukhovsky, Arkady
• Application Number:
  US10/496,944
• Publication Number:
  US 20050075555A1
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 1/00009 of image signals during a use of endoscope
• CPC Class Codes: A61B 1/04 combined with photographic or television appliances
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/14539 for measuring pH

Abstract

An apparatus, system and method that enables sensing and/or measuring environmental conditions in an in vivo environment. An environment sensitive material, such as a temperature sensitive color changing material, may be placed within or without of an in-vivo imaging device. The environment sensitive material may change in response to environmental changes, such as temperature changes, pH level changes, pressure changes etc., and the in-vivo imaging device may acquire these responses. These responses may be acquired by an imager, in the form of images that indicate the color status of the environment sensitive material for each data frame sent from the in-vivo imaging device to a data receiving unit and/or data processor. The data may be processed and analyzed etc. by a data processor, and output by an output device.

Claims

1. A system enabling in vivo environment sensing, comprising:

an in-vivo imaging device;

at least one environment sensitive color-changing material; and

at least one data transmitter.

2. The system of claim 1, wherein said in-vivo imaging device is at least one device selected from the group consisting of swallowable capsules, endoscopes, and catheters.

3. The system of claim 1, wherein said material is adhered to the device according to one or more ways selected from the group consisting of painting, adhering, welding, point-wise binding and spraying.

4. The system of claim 1, wherein said material is one or more materials selected from the group consisting of thermotropic color-changing liquid crystal, litmus paper, shear sensitive liquid crystal, and color changing irreversible material.

5. The system of claim 1, comprising a plurality of color-changing materials, to sense a plurality of environmental parameter changes.

6. The system of claim 5, wherein said environmental parameter changes include one or more parameters selected from the group consisting of in vivo temperature, in vivo pressure, in vivo pH level, and in-vivo bacteria level.

7. The system of claim 1, comprising:

at least one light source; and

at least one imager.

8. The system of claim 1, comprising:

at least one data receiver unit;

at least one data processing unit; and

at least one data output unit.

9. The system of claim 8, wherein said data processor unit comprises:

at least one colorimetric module; and

at least one calculator.

10. A system enabling in vivo sensing, comprising:

an in-vivo imaging device;

at least one environment sensitive color-changing material;

at least one data receiver unit;

at least one data processing unit; and

at least one data output unit.

11. The system of claim 10, wherein said data processing unit comprises:

at least one calorimetric module; and

at least one calculator.

12. A system enabling in vivo sensing, comprising:

means for indicating a change of at least one environmental parameter;

means for lighting said indicating means; and

means for acquiring in vivo images, said images including environmental parameter changes indicated by said indicating means.

13. The system of claim 12, wherein said means for indicating changes in at least one environmental parameter is a color changing material.

14. A method enabling in vivo sensing, comprising:

radiating light onto at least one color changing environment sensitive material coupled to an in-vivo imaging device;

acquiring a plurality of images from said material; and

transmitting said acquired images to a data receiving unit.

15. The method of claim 14, comprising:

receiving color change data from said in-vivo imaging device; and

calculating at least one parameter value from said color change data.

16. The method of claim 14, comprising processing said acquired data by a data processing unit.

17. The method of claim 16, wherein said processing said acquired data comprises:

calculating the color components of received data for each image received; and

comparing color component values for each image to at least one calibration.

18. The method of claim 16, wherein said processing said acquired data comprises:

calculating the color components of received data for each image received;

expressing the color components of each image according to at least one of hue, saturation and brightness;

comparing color component values for each image to at least one calibration curve generated from previous images; and

calculating values for each image received by said data receiving unit.

19. The method of claim 14, comprising outputting data relating to said environment parameter changes.

20. The method of claim 14, wherein said environment sensitive material is one or more color changing materials selected from the group consisting of temperature sensitive material, pressure sensitive material, pH sensitive material and bacteria sensitive material.

21. The method of claim 14, comprising generating a value for at least one environmental parameter for each image, and displaying said value for each image of acquired data.

22. The method of claim 21, comprising:

generating at least one environment parameter value for one or more acquired images; and

displaying at least one environment parameter map for one or more acquired images.

23. The method of claim 22, wherein said generation of at least one environment parameter map comprises:

receiving a plurality of image frames;

combining a plurality of frames to generate at least one image including colors relating to parameter changes across said plurality of frames;

generating at least one image representing an environment;

dividing said color image into a grid of pixels, each pixel relating to at least one image frame received;

calculating a color for each said pixel, according to image frames received; and

displaying said pixels as a map of parameter changes for said environment.

24. The method of claim 23, comprising displaying said map of parameters at each selected point in time.

25. A method enabling in vivo sensing, comprising:

receiving image data from an in-vivo imaging device, said device having at least one color changing environment sensitive material; and

outputting image-related data.

26. The method of claim 25, comprising:

receiving image data from a plurality of frames;

processing image data for each frame; and

comparing image data from two or more frames.

27. A method enabling in vivo sensing, comprising:

placing at least one environment sensitive material to an in-vivo imaging device;

sensing environmental parameter changes by said environment sensitive material;

acquiring data indicating said environment parameter changes from said environment sensitive material;

transmitting said acquired data to a data processing unit;

processing said acquired data by said data processing unit; and

outputting data relating to said environment parameter changes.

28. The method of claim 27, wherein said environment sensitive material is a color changing material.

29. A system enabling determining of in vivo environmental conditions, comprising:

a data receiver unit, to receive at least image data related to an environment sensitive color-changing material; and

a processing unit to process said data, thereby determining the in vivo environmental conditions.

30. The system of claim 29, comprising at least one output device.

31. The system of claim 29, comprising at least one storage unit.

32. The system of claim 29, wherein said processing unit comprises:

at least one colorimetric module; and

at least one calculator.

33. The system of claim 29, wherein said in vivo environmental conditions include one or more parameters selected from the group consisting of in vivo temperature, in vivo pressure, in vivo pH level, and in-vivo bacteria level.

34. A system enabling determining changes in vivo environmental conditions, comprising:

a data receiver unit, to receive at least data related to an environment sensitive color-changing material;

a processing unit to process said data, thereby calculating in vivo environmental changes; and

at least one data output device.

35. The system of claim 34, wherein said data comprises a plurality of frames, each of said frames including data of color status of said environmental sensitive color-changing material.

36. A system enabling determining of changes in vivo environmental conditions, comprising:

data receiving means for receiving at least data related to an environmental sensitive color-changing material;

data processing means for processing said data, thereby calculating changes in the in vivo environment; and

data output means for displaying data related to the in vivo environment.

37. The system of claim 36, wherein said processing means comprise:

colorimetric calculation means for determining color components of said data related to said environmental sensitive color-changing material;

calculator means for comparing hue values derived by said colorimetric calculation means to at least one calibration curve, and calculating environment parameter values for each data frame received by said data receiving means.