Patient sensory response evaluation for neuromodulation efficacy rating
First Claim
1. A method comprising:
- applying a first type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the first type of external sensory stimulation;
applying a second type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the second type of external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the first type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the first type of external sensory stimulation during simultaneous application of the first type of external sensory stimulation and the neuromodulation therapy;
applying neuromodulation therapy to the patient simultaneously with application of the second type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the second type of external sensory stimulation during simultaneous application of the second type of external sensory stimulation and the neuromodulation therapy;
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements.
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Accused Products
Abstract
The invention is directed to a technique for rating neuromodulation efficacy based on evaluation of the response of the patient to sensory stimuli with and without delivery of neuromodulation therapy. In addition, the invention may provide a system capable of delivering sensory stimuli on a quantitative basis in a coordinated manner with delivery of neuromodulation therapy. A device programmer may provide a platform for controlling delivery of the sensory stimuli, delivery of neuromodulation therapy, and generation of rating information for neuromodulation efficacy based on patient sensory response to the stimuli. In operation, the programmer controls application of selected sensory stimuli to the patient'"'"'s body and records the patient'"'"'s verbal or physiological responses to the stimuli. This invention can be used to be a diagnostic or prognostic test that a given neuromodulation therapy, such as neurostimulation or drug delivery, is and will be successful.
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Citations
70 Claims
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1. A method comprising:
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applying a first type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the first type of external sensory stimulation;
applying a second type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the second type of external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the first type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the first type of external sensory stimulation during simultaneous application of the first type of external sensory stimulation and the neuromodulation therapy;
applying neuromodulation therapy to the patient simultaneously with application of the second type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the second type of external sensory stimulation during simultaneous application of the second type of external sensory stimulation and the neuromodulation therapy;
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system comprising:
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a first sensory stimulation unit to apply a first type of external sensory stimulation to a patient;
a second sensory stimulation unit to apply a second type of external sensory stimulation to the patient;
a neuromodulation unit to apply neuromodulation therapy to the patient;
a device to obtain a baseline measurement of patient sensory response to the first type of external sensory stimulation without application of the neuromodulation therapy, obtain a baseline measurement of patient sensory response to the second type of external sensory stimulation without application of the neuromodulation therapy, obtain a test measurement of patient sensory response to simultaneous application of the first type of external sensory stimulation and the neuromodulation therapy, obtain a test measurement of patient sensory response to simultaneous application of the second type of external sensory stimulation and the neuromodulation therapy, and evaluate efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method comprising:
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applying external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, chemical stimulation;
obtaining a baseline measurement of patient sensory response to the external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the external sensory stimulation;
obtaining a test measurement of patient sensory response to the external sensory stimulation during simultaneous application of the external sensory stimulation and the neuromodulation therapy; and
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A system comprising:
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a sensory stimulation unit to apply external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, chemical stimulation;
a neuromodulation unit to apply neuromodulation therapy to the patient;
a device to obtain a baseline measurement of patient sensory response to the external sensory stimulation without application of the neuromodulation therapy, obtain a test measurement of patient sensory response to simultaneous application of the external sensory stimulation and the neuromodulation therapy, and evaluate efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. A method comprising:
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applying a first type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the first type of external sensory stimulation;
applying a second type of external sensory stimulation to a patient;
obtaining a baseline measurement of patient sensory response to the second type of external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the first type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the first type of external sensory stimulation during simultaneous application of the first type of external sensory stimulation and the neuromodulation therapy;
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements for the first type of external sensory stimulation;
if the evaluation indicates efficacy, applying neuromodulation therapy to the patient simultaneously with application of the second type of external sensory stimulation;
obtaining a test measurement of patient sensory response to the second type of external sensory stimulation during simultaneous application of the second type of external sensory stimulation and the neuromodulation therapy; and
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements for the first and second types of external sensory stimulation.
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64. A system comprising:
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a first sensory stimulation unit to apply a first type of external sensory stimulation to a patient;
a second sensory stimulation unit to apply a second type of external sensory stimulation to the patient;
a neuromodulation unit to apply neuromodulation therapy to the patient;
a device to obtain a baseline measurement of patient sensory response to the first type of external sensory stimulation without application of the neuromodulation therapy, obtain a baseline measurement of patient sensory response to the second type of external sensory stimulation without application of the neuromodulation therapy, obtain a test measurement of patient sensory response to simultaneous application of the first type of external sensory stimulation and the neuromodulation therapy, evaluate efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements, wherein device, if the evaluation indicates efficacy, obtains a test measurement of patient sensory response to simultaneous application of the second type of external sensory stimulation and the neuromodulation therapy, and evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements and the test measurements for the first and second types of external sensory stimulation.
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65. A method comprising:
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applying external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, and chemical stimulation;
obtaining a baseline measurement of patient sensory response to the external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the external sensory stimulation;
obtaining a test measurement of patient sensory response to the external sensory stimulation during simultaneous application of the external sensory stimulation and the neuromodulation therapy; and
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements, the test measurements, and a patient report of pain relief. - View Dependent Claims (66)
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67. A system comprising:
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a sensory stimulation unit to apply external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, and chemical stimulation;
a neuromodulation unit to apply neuromodulation therapy to the patient simultaneously with application of the external sensory stimulation; and
a device to obtain a baseline measurement of patient sensory response to the external sensory stimulation, obtain a test measurement of patient sensory response to the external sensory stimulation during simultaneous application of the external sensory stimulation and the neuromodulation therapy, and evaluate efficacy of the neuromodulation therapy based on a comparison of the baseline measurements, the test measurements, and a patient report of pain relief. - View Dependent Claims (68)
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69. A method comprising:
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applying external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, electrical, and chemical stimulation;
obtaining a baseline measurement of patient sensory response to the external sensory stimulation;
applying neuromodulation therapy to the patient simultaneously with application of the external sensory stimulation;
obtaining a test measurement of patient sensory response to the external sensory stimulation during simultaneous application of the external sensory stimulation and the neuromodulation therapy; and
evaluating efficacy of the neuromodulation therapy based on a comparison of the baseline measurements, the test measurements, and a visual analog scale (VAS) score.
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70. A system comprising:
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a sensory stimulation unit to apply external sensory stimulation to a patient, wherein the external sensory stimulation includes at least one of tactile, vibrational, thermal, pressure, electrical, and chemical stimulation;
a neuromodulation unit to apply neuromodulation therapy to the patient simultaneously with application of the external sensory stimulation; and
a device to obtain a baseline measurement of patient sensory response to the external sensory stimulation, obtain a test measurement of patient sensory response to the external sensory stimulation during simultaneous application of the external sensory stimulation and the neuromodulation therapy, and evaluate efficacy of the neuromodulation therapy based on a comparison of the baseline measurements, the test measurements, and a visual analog scale (VAS) score.
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Specification