Method and apparatus for controlling extra-systolic stimulation (ESS) therapy using ischemia detection

• US 20050075673A1
• Filed: 10/07/2003
• Published: 04/07/2005
• Est. Priority Date: 10/07/2003
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Stadler, Robert W., Warkentin, Dwight H., Deno, D. Curtis, Zillmer, Glenn C.
• Application Number:
  US10/680,462
• Publication Number:
  US 20050075673A1
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

An implantable cardiac stimulation device capable of delivering ESS, monitoring for myocardial ischemia and responding to the detection of myocardial ischemia by modifying the delivery of ESS. Modification of ESS delivery may include disabling ESS, initiating ESS, and/or modifying ESS control parameters.

Claims

1. A method for controlling extra systolic stimulation (ESS) therapy delivery, comprising the steps of:

detecting myocardial ischemia; and

responding to the myocardial ischemia detection by modifying the delivery of ESS therapy.

2. A method according to claim 1, wherein modifying the delivery of ESS comprises any of:

disabling ESS therapy delivery;

initiating ESS therapy delivery;

modifying at least one ESS therapy delivery control parameter.

3. A method according to claim 1, further comprising:

detecting the absence of myocardial ischemia subsequent to an initial affirmative ischemia detection; and

modifying ESS therapy delivery.

4. A method of adapting an extra-systolic stimulation (ESS) therapy delivery sequence in response to an ischemia monitors output signal, comprising:

monitoring a volume of myocardial tissue for a myocardial ischemic condition and providing an output signal related to a presence or an absence of a myocardial ischemia condition;

in the event that the output signal indicates the presence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, at least temporarily ceasing further delivery of the ESS therapy; and

in the event that the output signal indicates the presence of the myocardial ischemic condition and the ESS therapy is not presently being applied to the volume of myocardial tissue, initiating delivery of the ESS therapy.

5. A method according to claim 4, further comprising:

in the event that the output signal indicates the absence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, then either;

continuing delivery of the ESS therapy, or

mode-switching to another cardiac stimulation therapy modality.

6. A method according to claim 4, wherein the monitoring step further comprises:

determining a variation in;

a cardiac conduction interval from pacing pulse delivery to resultant depolarization over at least two different cardiac cycles,

a present sensor signal output compared to a prior sensor signal output, wherein said sensor couples to a portion of myocardial tissue and comprises one of;

a mechanical sensor, a biological sensor, a metabolic sensor;

a variation in S-T segment parameters relative to an isoelectric baseline parameter, or

a variation in a portion of a T-wave of a PQRST complex, using a cardiac electrogram signal vector for determining the onset, presence or absence of an ischemia condition.

7. A method according to claim 6, wherein the cardiac electrogram vector comprises at least a one of:

a tip-to-ring electrode vector, a coil-to-can electrode vector, a coil-to-coil electrode vector, a tip-to-can electrode vector, a ring-to-can electrode vector, a ring-to-ring vector.

8. A method according to claim 7, wherein said method is performed on a computer readable medium disposed within an implantable pulse generator.

9. A method according to claim 8, further comprising:

wirelessly transmitting the output signal to a remote device; and

/or

vibrating the implantable pulse generator in relation to a state change in the output signal.

10. A method according to claim 9, further comprising:

displaying an indicia by or on the remote device, wherein said indicia comprises a visual indicia related to the output signal.

11. A computer readable medium for storing executable instructions for performing a method, comprising:

instructions for monitoring a volume of myocardial tissue for a myocardial ischemic condition and providing an output signal related to a presence or an absence of a myocardial ischemia condition;

in the event that the output signal indicates the presence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, instructions for at least temporarily ceasing further delivery of the ESS therapy; and

in the event that the output signal indicates the presence of the myocardial ischemic condition and the ESS therapy is not presently being applied to the volume of myocardial tissue, instructions for initiating delivery of the ESS therapy.

12. A method according to claim 11, further comprising:

in the event that the output signal indicates the absence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, then either;

instructions for continuing delivery of the ESS therapy, or instructions for mode-switching to another cardiac stimulation therapy modality.

13. A method according to claim 11, wherein the monitoring step further comprises:

instructions for determining;

a variation in a cardiac conduction interval from pacing pulse delivery to resultant depolarization over at least two different cardiac cycles,

a variation in a present sensor signal output compared to a prior sensor signal output, wherein said sensor couples to a portion of myocardial tissue and comprises one of;

a mechanical sensor, a biological sensor, a metabolic sensor;

a variation in S-T segment parameters relative to an isoelectric baseline parameter, or

a variation in a portion of a T-wave of a PQRST complex,

wherein said variation is determined based upon a cardiac electrogram signal vector for determining the onset, presence or absence of an ischemia condition.

14. A method according to claim 13, wherein the cardiac electrogram vector comprises at least a one of:

a tip-to-ring electrode vector, a coil-to-can electrode vector, a coil-to-coil electrode vector, a tip-to-can electrode vector, a ring-to-can electrode vector, a ring-to-ring vector.

15. A method according to claim 14, further comprising:

instructions for wirelessly transmitting the output signal to a remote device; and

/or

instructions for vibrating the implantable pulse generator in relation to a state change in the output signal.

16. A method according to claim 15, further comprising:

instructions for displaying an indicia by or on the remote device, wherein said indicia comprises a visual indicia related to the output signal.

17. A method according to claim 15, wherein said remote device is coupled to a clinician information network.

18. An apparatus for providing an adaptable extra-systolic stimulation (ESS) therapy delivery sequence in response to an output signal from a myocardial ischemia monitor, comprising:

means for monitoring a volume of myocardial tissue for a myocardial ischemic condition and providing an output signal related to a presence or an absence of a myocardial ischemia condition;

means for, in the event that the output signal indicates the presence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, at least temporarily ceasing further delivery of the ESS therapy; and

means for, in the event that the output signal indicates the presence of the myocardial ischemic condition and the ESS therapy is not presently being applied to the volume of myocardial tissue, initiating delivery of the ESS therapy.

19. An apparatus according to claim 18, further comprising:

means for, in the event that the output signal indicates the absence of the myocardial ischemic condition and an ESS therapy is presently being applied to the volume of myocardial tissue, then either continuing delivery of the ESS therapy, or mode-switching to another cardiac stimulation therapy modality.

20. An apparatus according to claim 18, further comprising means for determining a variation in:

a cardiac conduction interval from pacing pulse delivery to resultant depolarization over at least two different cardiac cycles,

a present sensor signal output compared to a prior sensor signal output, wherein said sensor couples to a portion of myocardial tissue and comprises one of;

a mechanical sensor, a biological sensor, a metabolic sensor;

a variation in S-T segment parameters relative to an isoelectric baseline parameter, or

a variation in a portion of a T-wave of a PQRST complex,

using a cardiac electrogram signal vector for determining the onset, presence or absence of an ischemia condition.

21. An apparatus according to claim 20, wherein the cardiac electrogram vector comprises at least a one of:

a tip-to-ring electrode vector, a coil-to-can electrode vector, a coil-to-coil electrode vector, a tip-to-can electrode vector, a ring-to-can electrode vector, a ring-to-ring vector.

22. An apparatus according to claim 21, further comprising:

means for wirelessly transmitting the output signal to a remote device;

or

means for vibrating the implantable pulse generator in relation to a state change in the output signal.

23. An apparatus according to claim 22, further comprising:

means for displaying an indicia by or on the remote device, wherein said indicia comprises a visual indicia related to the output signal.

24. An apparatus according to claim 22, wherein said remote device is coupled to a clinician information network.