Device and method for inhibiting release of pro-inflammatory mediator
First Claim
1. A method for inhibiting the release of a proinflammatory mediator from a mammalian cell, the method comprising stimulating a sympathetic neuron of a mammalian subject in an amount effective to inhibit the release of the proinflammatory mediator.
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Abstract
Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, to attenuate an immune response, including an inflammatory immune response, is discussed. Devices and systems to stimulate the sympathetic nervous system to attenuate an immune response are also discussed. Devices discussed include pulse generators and drug pumps. Systems are described as optionally having one or more sensors and operator instructions. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.
362 Citations
69 Claims
- 1. A method for inhibiting the release of a proinflammatory mediator from a mammalian cell, the method comprising stimulating a sympathetic neuron of a mammalian subject in an amount effective to inhibit the release of the proinflammatory mediator.
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27. A method of inhibiting an inflammatory cytokine cascade in a patient, comprising:
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stimulating a sympathetic neuron in the patient in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the patient is suffering from, or at risk for, a disease or disorder mediated by the inflammatory cytokine cascade. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
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Specification