Dual use detectors for flow cytometry
First Claim
Patent Images
1. A detection system comprising:
- a light source arrangement for providing a light beam proximate to a flow channel for containing a core stream;
a detection mechanism proximate to the flow channel; and
an alignment affecter for shifting the light beam and a core stream relative to each other; and
wherein the detection mechanism may detect light about alignment between the light beam and the core stream, and detect light containing information about the core stream.
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Abstract
An optical alignment system for aligning a light beam with a core flow in a flow stream. The flow stream may have a sheath fluid and a core flow, where the core flow has a current position within the flow stream. A light source may be used to produce a light beam, and an optical element may be used to direct the light beam at the core flow. In some illustrative embodiments, an actuator is provided for moving the optical element, light source and/or flow stream such that the light directed by the optical element is aligned with the current position of the core flow.
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Citations
40 Claims
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1. A detection system comprising:
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a light source arrangement for providing a light beam proximate to a flow channel for containing a core stream;
a detection mechanism proximate to the flow channel; and
an alignment affecter for shifting the light beam and a core stream relative to each other; and
wherein the detection mechanism may detect light about alignment between the light beam and the core stream, and detect light containing information about the core stream. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of alignment and parameter detection, comprising:
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emanating a light beam to a flow channel;
detecting light from a core stream in the flow channel;
adjusting an alignment of the light beam and the core stream according to detected light; and
obtaining information about the core stream from detected light. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. A detection system comprising:
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a light source mechanism for providing a light beam proximate to a flow channel;
a detection mechanism proximate to the flow channel; and
an alignment mechanism for adjusting an alignment of the light beam and a core stream of the flow channel; and
wherein the detection mechanism may detect light indicative of the alignment of the light beam and the core stream, and detect light about parameters of a core stream in the flow channel. - View Dependent Claims (29, 30, 31)
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32. Means for alignment and parameter detection, comprising:
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means for emanating a light beam to a flow channel;
means for detecting light scattered by a core stream in the flow channel;
means for determining an amount of alignment between the light beam and the core stream according to detected light from the means for detecting light;
means for changing the amount of alignment between the light beam and the core stream according to the detected light; and
means for obtaining parameter information about the core stream from the detected light. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39)
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40. A detection system comprising:
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a light source mechanism for providing a light beam proximate to a flow channel;
a detection mechanism proximate to the flow channel;
a first alignment mechanism for adjusting an alignment of the light beam relative to the flow channel, according to detected light from the detection mechanism;
a second alignment mechanism for adjusting an alignment of the light beam relative to a core stream of the flow channel, according to detected light from the detection mechanism; and
a parameter mechanism for determining parameters of the core stream according to detected light from the detection mechanism.
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Specification