Dimeric and multimeric antigen binding structure
First Claim
Patent Images
1. A multimeric structure comprising two or more identical protein monomers, characterized by the following features:
- (a) the monomers of said structure comprise at least four variable domains of which the first or last two variable domains of which the first or last two variable domains form an antigen-binding VH-VL or VL-VH scFv unit wherein two variable domains are linked by a peptide linker of at least 5 amino acid residues which does not prevent the intramolecular formation of a scFv;
(b) the other two neighboring variable domains of the monomer are non-covalently bound to the complementary domains of another monomer resulting in the formation of at least two additional antigen binding sites to form the multimerisation motif.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to dimeric and multimeric antigen binding structures, expression vectors encoding said structures, and diagnostic, as well as therapeutic, uses of said structures. The antigen binding structures are preferably in the form of a Fv-antibody construct.
78 Citations
25 Claims
-
1. A multimeric structure comprising two or more identical protein monomers, characterized by the following features:
-
(a) the monomers of said structure comprise at least four variable domains of which the first or last two variable domains of which the first or last two variable domains form an antigen-binding VH-VL or VL-VH scFv unit wherein two variable domains are linked by a peptide linker of at least 5 amino acid residues which does not prevent the intramolecular formation of a scFv;
(b) the other two neighboring variable domains of the monomer are non-covalently bound to the complementary domains of another monomer resulting in the formation of at least two additional antigen binding sites to form the multimerisation motif. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
Specification