Polymer micelle as monolayer or layer-laminated surface
First Claim
1. A coated biomedical device wherein the coating comprises at least one polymeric micelle immobilized to the surface of said biomedical device, said micelle having either a hydrophilic core and hydrophobic shell or a hydrophobic core and a hydrophilic shell, said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40.
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Accused Products
Abstract
The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
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Citations
72 Claims
- 1. A coated biomedical device wherein the coating comprises at least one polymeric micelle immobilized to the surface of said biomedical device, said micelle having either a hydrophilic core and hydrophobic shell or a hydrophobic core and a hydrophilic shell, said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40.
- 30. A method for reducing protein contamination of a biomedical device after insertion in an animal, said method comprises coating said biomedical device with a protein adsorption inhibiting effective amount of polymeric micelle immobilized on the surface of said biomedical device, said micelle having a hydrophilic outer shell and a hydrophobic inner core or a hydrophobic outer shell and a hydrophilic inner core, said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40.
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- 67. A method for reducing microbial contamination of a biomedical device after insertion in an animal, said method comprises coating said biomedical device with an anti-microbial effective amount of a polymeric micelle, said micelle having either an hydrophilic outer shell and a hydrophobic inner core or a hydrophobic outer shell and a hydrophilic inner core, said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40.
Specification