CaO-MgO-SiO2-based bioactive glass and sintered calcium phosphate glass using same

• US 20050079226A1
• Filed: 10/13/2004
• Published: 04/14/2005
• Est. Priority Date: 10/14/2003
• Status: Active Grant

• Current Assignee: Pentax Corporation (Hoya Corporation), Tadashi Kokubo
• Original Assignee: Pentax Corporation (Hoya Corporation), Tadashi Kokubo
• Inventors: Kokubo, Tadashi, Ogawa, Tetsuro, Gonda, Yukiko
• Granted Patent: US 7,214,635 B2
• Time in Patent Office: Days
• US Class Current: 424/602
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: C03C 10/16 Halogen containing crystalline phase
• CPC Class Codes: C03C 3/112 containing fluorine
• CPC Class Codes: C03C 4/0007 for biologically-compatible glass

Abstract

A bioactive glass having a composition substantially comprising 20 to 40 mol % of CaO, 40 to 60 mol % of SiO₂, and 10 to 20 mol % of MgO is high in bioactivity and mechanical strength, and a sintered calcium phosphate glass using the bioactive glass as a sintering aid is excellent in biocompatibility and mechanical strength.

Claims

1. A bioactive glass having a composition comprising 20 to 40 mol % of CaO, 40 to 60 mol % of SiO₂, and 10 to 20 mol % of MgO.

2. The bioactive glass according to claim 1, further comprising CaF₂.

3. The bioactive glass according to claim 1, further comprising Na₂O.

4. The bioactive glass according to claim 1, further comprising B₂O₃.

5. The bioactive glass according to claim 1, wherein said bioactive glass has a glass transition temperature of 650 to 750°

C.

6. The bioactive glass according to claim 1, wherein a difference between its glass transition temperature and its crystallization initiation temperature is 70 to 250°

C.

7. The bioactive glass according to claim 1, wherein said bioactive glass generates a β

-wollastonite crystal and a diopside crystal.

8. The bioactive glass according to claim 1, wherein said bioactive glass contains 5 mol % or less of P₂O₅.

9. A sintered calcium phosphate glass comprising the bioactive glass recited in claim 1 as a sintering aid.

10. The sintered calcium phosphate glass according to claim 9, wherein said sintered calcium phosphate glass comprises at least one calcium phosphate component selected form the group consisting of hydroxyapatites, carbonated apatites and tricalcium phosphate.

11. The sintered calcium phosphate glass according to claim 9, wherein a β

-wollastonite crystal and a diopside crystal are generated in said bioactive glass.