Liquid crystals with reduced toxicity and applications thereof
First Claim
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1. A liquid crystal composition, comprising:
- at least two different liquid crystal compounds, wherein the first liquid crystal and the second liquid crystal both comprise at least one fluorine group, and at least one of the first liquid crystal and the second liquid crystal comprises a fluorinated phenyl group.
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Abstract
Liquid crystal compositions that exhibit little or no toxicity with respect to cells include liquid crystals with chemical functional groups such as fluorine atoms, fluorophenyl groups, or difluorophenyl groups. Liquid crystals with little or no toxicity to cell lines may be added to cell culture media or added to components used in cell culture media. Cells may be grown in cell culture media that includes liquid crystals that exhibit little or no toxicity to cells.
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Citations
77 Claims
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1. A liquid crystal composition, comprising:
- at least two different liquid crystal compounds, wherein the first liquid crystal and the second liquid crystal both comprise at least one fluorine group, and at least one of the first liquid crystal and the second liquid crystal comprises a fluorinated phenyl group.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- 16. A liquid crystal cell culture media, comprising at least one liquid crystal compound and at least one cell culture component selected from a vitamin, an amino acid, a sugar, or combinations thereof, wherein the at least one liquid crystal includes at least one fluorine group, is a cholesteric liquid crystal, or is a liquid crystal that exhibits reduced toxicity towards cells.
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33. A kit for growing cells, comprising:
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(a) at least one liquid crystal selected from a cholesteric liquid crystal, a liquid crystal that comprises at least one fluorine atom, or a liquid crystal that exhibit reduced toxicity towards cells; and
(b) a cell culture medium comprising at least one cell culture component selected from a vitamin, an amino acid, a sugar, or combinations thereof. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A composition, comprising:
- a virus or a cell, a compound of formula I or a salt thereof, and a cell culture component selected from a vitamin, an amino acid, a sugar, or combinations thereof, wherein the compound of formula I has the following formula
- View Dependent Claims (58, 59, 60, 61)
- 62. A method for investigating viruses, comprising contacting a virus with a compound of formula I or a salt thereof, wherein the compound of formula I has the following formula
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65. A method for detecting interactions between a biomolecule and a receptor, comprising:
(a) contacting an aqueous solution comprising water, a liquid crystal, and a biomolecule with a surface that uniformly orients the liquid crystal when the biomolecule does not bind to a receptor, wherein the receptor is either bound to the surface or is included in the aqueous solution, further wherein the surface resists adsorption of the biomolecule if the biomolecule does not bind to the receptor, but the biomolecule will be bound to the surface if the receptor is bound to the surface and the receptor binds the biomolecule, further wherein if the biomolecule binds to the receptor in the absence of the liquid crystal, then the biomolecule will still bind to the receptor in the presence of the liquid crystal. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
Specification