Apparatus for treatment of light-sensitive biopolymers

• US 20050079601A1
• Filed: 08/25/2004
• Published: 04/14/2005
• Est. Priority Date: 02/26/2002
• Status: Abandoned Application

• Current Assignee: Flexgen Technologies B.V. (Piculet Biosciences BV)
• Original Assignee: Flexgen Technologies B.V. (Piculet Biosciences BV)
• Inventors: Den Dunnen, Johannes Theodorus, Heemskerk, Cornelis Jacobus Maria, Van Boom, Jacobus Hubertus
• Application Number:
  US10/925,528
• Publication Number:
  US 20050079601A1
• Time in Patent Office: Days
• US Class Current: 435/287.200
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00439 using micromirror arrays
• CPC Class Codes: B01J 2219/00441 using lasers
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/0059 Sequential processes
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/00608 DNA chips
• CPC Class Codes: B01J 2219/0061 The surface being organic
• CPC Class Codes: B01J 2219/00612 the surface being inorganic
• CPC Class Codes: B01J 2219/00637 by coating it with another layer
• CPC Class Codes: B01J 2219/00639 the compounds being trapped in or bound to a porous medium
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00689 using computers
• CPC Class Codes: B01J 2219/00711 Light-directed synthesis
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C40B 40/06 Libraries containing nucleotides or polynucleotides, or derivatives thereof
• CPC Class Codes: C40B 60/14 for creating libraries

Abstract

The invention relates to an apparatus for treating light-sensitive biopolymers, comprising at least a light source, a process chamber suitable for receiving a substrate on which the biopolymers are placed for treatment with light from the light source, and an allocation member for directing the light from the light source to the selected sites on the substrate.

Claims

1. An apparatus for treating light-sensitive biopolymers, comprising at least a light source, a process chamber suitable for receiving a substrate on which the biopolymers are placed for treatment with light from the light source, and an allocation member for directing the light from the light source to selected sites on the substrate, wherein the allocation member comprises at least one motor-driven mirror, the mirror is mounted on a rotatable spool arranged between poles of a device generating a magnetic field, and the allocation member has an adjustable source of electricity connected with the spool for controlling orientation of the mirror.

2. An apparatus according to claim 1, wherein orientation of the mirror is adjustable to a predetermined position corresponding with a selected illumination site on the substrate.

3. An apparatus according to claim 1, wherein the allocation member is a galvanomirror.

4. An apparatus according to claim 1, wherein the motor of the mirror is temperature-stabilized.

5. An apparatus according to claim 1, wherein a focusing lens is placed on an optical path between the mirror and the substrate.

6. An apparatus according to claim 1, wherein the light source is an ultraviolet light source.

7. An apparatus according to claim 6, wherein the ultraviolet light source operates in the 340-390 nm range.

8. An apparatus according to claim 7, wherein the ultraviolet light source is a frequency-trebled Nd:

YAG laser.

12. An apparatus according to claim 5, wherein the focusing leans is an F-theta-lens.

13. An apparatus according to claim 7, wherein the ultraviolet light source operates at approximately 350 nm.

9. A Method for treating light-sensitive biopolymers, using at least a light source, a process chamber suitable for receiving a substrate on which the biopolymers are directing the light from the light source to selected sites on the substrate, wherein for the allocation member use is made of at least one motor-driven mirror which is mounted on a rotatable spool arranged between poles of a device generating a magnetic field, wherein orientation of the mirror is controlled by connecting an adjustable source of electricity to the spool.

10. A method according to claim 9, wherein orientation of the mirror is adjusted to a predetermined position corresponding with a selected illumination site on the substrate.

11. A method according to claim 9, wherein in use temperature of the motor of the mirror is stabilized.