Sustained release pharmaceutical compounds to prevent abuse of controlled substances
First Claim
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1. A pharmaceutical composition comprising:
- a controlled substance; and
an amino acid or polypeptide covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive.
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Abstract
The present invention provides methods for altering controlled substances in a manner that decreases their potential for abuse. The novel compounds may be combined in tablets with suitable excipients or formulated in solution for oral delivery. When delivered by the oral route the controlled substance is released in a time-dependent manner (sustained release) by acid hydrolysis and/or enzymatic cleavage. When administered by injection the controlled substance is released in a time-dependent manner (sustained release) by way of serum enzymes.
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Citations
31 Claims
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1. A pharmaceutical composition comprising:
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a controlled substance; and
an amino acid or polypeptide covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification