Nitric oxide donating derivatives for the treatment of cardiovascular disorders

• US 20050080024A1
• Filed: 03/24/2004
• Published: 04/14/2005
• Est. Priority Date: 08/15/2002
• Status: Abandoned Application

• Current Assignee: Resverlogix Corp.
• Original Assignee: Resverlogix Corp.
• Inventors: McCaffrey, David, Wong, Norman C.W., Tucker, Joseph
• Application Number:
  US10/807,800
• Publication Number:
  US 20050080024A1
• Time in Patent Office: Days
• US Class Current: 514/27
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07C 211/52 the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
• CPC Class Codes: C07C 235/56 having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07C 235/64 having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07C 239/20 having oxygen atoms of hydroxylamino groups etherified
• CPC Class Codes: C07C 243/22 having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
• CPC Class Codes: C07C 245/08 with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
• CPC Class Codes: C07C 311/21 having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07C 317/22 with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• CPC Class Codes: C07C 323/20 with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
• CPC Class Codes: C07D 311/32 2,3-Dihydro derivatives, e.g. flavanones

Abstract

Compounds comprising nitric oxide derivatives of stilbenes, polyphenols and flavonoids and methods of their use are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.

Claims

1. A flavonoid compound comprising the structure:

2. A pharmaceutical composition comprising the flavonoid compound of claim 1 in combination with a pharmaceutically acceptable carrier.

3. A method for treating cardiovascular, cholesterol or lipid related disorders in a patient comprising administering to a patient in need of treatment a therapeutically effective amount of a flavonoid compound according to claim 1.

4. A method for inducing expression of ApoAl while providing anti-oxidant activity in a patient comprising administering to said patient a flavonoid compound according to claim 1.

5. A method for reducing serum cholesterol in a patient comprising administering to said patient a flavonoid compound according to claim 1.

6. An isoflavonoid compound comprising the structure:

7. A pharmaceutical composition comprising the isoflavonoid compound of claim 6 in combination with a pharmaceutically acceptable carrier.

8. A method for treating cardiovascular, cholesterol or lipid related disorders in a patient comprising administering to a patient in need of treatment a therapeutically effective amount of an isoflavonoid compound according to claim 6.

9. A method for inducing expression of ApoAl while providing anti-oxidant activity in a patient comprising administering to said patient an isoflavonoid compound according to claim 6.

10. A method for reducing serum cholesterol in a patient comprising administering to said patient an isoflavonoid compound according to claim 6.

11. A stilbene compound comprising the following structure:

12. A pharmaceutical composition comprising the a stilbene compound of claim 11 in combination with a pharmaceutically acceptable carrier.

13. A method for treating cardiovascular, cholesterol or lipid related disorders in a patient comprising administering to a patient in need of treatment a therapeutically effective amount of a stilbene compound according to claim 11.

14. A method for inducing expression of ApoAl while providing anti-oxidant activity in a patient comprising administering to said patient a stilbene compound according to claim 11.

15. A method for reducing serum cholesterol in a patient comprising administering to said patient a stilbene compound according to claim 11.