Methods and apparatus for mixing of liquids
First Claim
1. An apparatus for mixing fluids, said apparatus comprising:
- (a) a housing having an interior channel with capillary dimensions, (b) a structural member in said interior channel adjacent an end thereof, the dimensions of and placement of said structural member being sufficient such that intermittent application of centrifugal force to said interior causes movement of said fluid in said channel without exit thereof, and (c) a mechanism that intermittently generates centrifugal force on the interior of said housing to cause movement of said fluid in said channel without exit thereof.
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Accused Products
Abstract
An apparatus for mixing fluids comprises a housing having at least a portion of its interior, for example, a channel, with capillary dimensions and at least one structural member in the interior adjacent an end of the channel. The dimensions of and placement of the structural member are sufficient such that intermittent application of centrifugal force to the interior of the housing causes movement of the fluid therein. The housing may comprise a mixing chamber or area that is in fluid communication with the interior. The apparatus may comprise a mechanism adapted to generate centrifugal force within the housing to cause movement of fluid in the interior of the housing without exit of fluid therefrom.
33 Citations
29 Claims
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1. An apparatus for mixing fluids, said apparatus comprising:
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(a) a housing having an interior channel with capillary dimensions, (b) a structural member in said interior channel adjacent an end thereof, the dimensions of and placement of said structural member being sufficient such that intermittent application of centrifugal force to said interior causes movement of said fluid in said channel without exit thereof, and (c) a mechanism that intermittently generates centrifugal force on the interior of said housing to cause movement of said fluid in said channel without exit thereof. - View Dependent Claims (2, 3, 4, 5, 6, 12, 13, 14, 15)
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7. An apparatus for conducting hybridization reactions, said apparatus comprising:
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(a) a housing having an interior channel with capillary dimensions, said interior channel comprising a linear microarray of biopolymers for conducting hybridization reactions and a mixing area, (b) a structural member in said interior channel adjacent an end thereof, the dimensions of and placement of said structural member being sufficient such that intermittent application of centrifugal force to said interior channel causes movement of said fluid in said interior channel between said linear microarray and said mixing area without exit of fluid from said interior channel, and (c) a mechanism that intermittently generates centrifugal force on the interior of said housing to cause movement of said fluid in said interior channel between said linear microarray and said mixing area without exit of fluid from said interior channel. - View Dependent Claims (8, 9, 10, 11)
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16. A method for conducting hybridization reactions, said method comprising:
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(a) introducing a sample into a housing comprising a linear microarray of features for hybridizing to analytes in said sample, said housing having internal capillary dimensions, a mixing area separate from said linear array and a structural member in said interior adjacent an end thereof, the dimensions of and placement of said structural member being sufficient such that intermittent application of centrifugal force to said interior causes motion of said fluid therein, and (b) incubating said sample in said housing under conditions for carrying out said hybridization reactions and during said incubation generating intermittent centrifugal force to cause reciprocal movement of said fluid between said linear array and said mixing area but insufficient to cause said fluid to exit said housing. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification