Bioarray chip reaction apparatus and its manufacture
First Claim
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1. A method of making probe chips comprising the steps of:
- forming a plurality of probe arrays on a wafer;
separating said wafer into a plurality of chips, each of said chips comprising at least one probe array thereon; and
mating at least one of said chips to a package, said package comprising a reaction chamber, said reaction chamber comprising inlets for flowing fluid therein, said at least one probe array in fluid communication with said reaction chamber.
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Abstract
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
76 Citations
105 Claims
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1. A method of making probe chips comprising the steps of:
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forming a plurality of probe arrays on a wafer;
separating said wafer into a plurality of chips, each of said chips comprising at least one probe array thereon; and
mating at least one of said chips to a package, said package comprising a reaction chamber, said reaction chamber comprising inlets for flowing fluid therein, said at least one probe array in fluid communication with said reaction chamber.
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2-92. -92. (canceled)
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93. A septum penetrable by a member and which maintains a seal following member penetration in an axial direction and withdrawal, comprising:
- a first layer of resilient material having first and second opposed surfaces; and
a second continuous layer extending across, and bonded to, the first surface of the first layer and which is in radial tension to hold the first layer in radial compression. - View Dependent Claims (94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105)
- a first layer of resilient material having first and second opposed surfaces; and
Specification