Mediators of hedgehog signaling pathways, compositions and uses related thereto
First Claim
1. A method for inhibiting activation of a hedgehog pathway in a cell, comprising contacting the cell with a hedgehog antagonist in a sufficient amount to inhibit hedgehog signalling, wherein the hedgehog antagonist is a organic molecule represented in the general formula (I):
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Abstract
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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Citations
36 Claims
- 1. A method for inhibiting activation of a hedgehog pathway in a cell, comprising contacting the cell with a hedgehog antagonist in a sufficient amount to inhibit hedgehog signalling, wherein the hedgehog antagonist is a organic molecule represented in the general formula (I):
- 17. A method for inhibiting activation of a hedgehog pathway in a cell, comprising contacting the cell with a hedgehog antagonist in a sufficient amount to inhibit hedgehog signalling, wherein the hedgehog antagonist is a organic molecule represented in the general formula (II):
- 32. A pharmaceutical preparation comprising a sterile pharmaceutical excipient and a compound represented by the general formula (I):
- 34. A pharmaceutical preparation comprising a sterile pharmaceutical excipient and a compound represented by the general formula (II):
Specification