Evaluating disease progression using magnetic resonance imaging
First Claim
1. An orthopedic magnetic resonance imaging system, comprising:
- a source of magnetic resonance imaging data sets resulting from successive magnetic resonance imaging acquisitions from a diseased joint of a patient, a segmentation module responsive to the source of magnetic resonance imaging data sets and operative to segment surfaces in the joint based on information contained within at least one of the data sets, a registration module responsive to the source of magnetic resonance imaging data sets and operative to spatially register, in three dimensions, information represented by a first of the data sets with respect to information represented by one or more further data sets for the same patient, and a comparison module responsive to the registration module and operative to detect differences between information represented by the data sets caused by progression of the disease in the joint of the patient between acquisitions.
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Abstract
An orthopedic magnetic resonance imaging system is disclosed. This system includes a source of magnetic resonance imaging data sets resulting from successive magnetic resonance imaging acquisitions from a diseased joint of a patient. A segmentation module segments surfaces in the joint based on information contained within at least one of the data sets, and a registration module spatially registers, in three dimensions, information represented by a first of the data sets with respect to information represented by one or more further data sets for the same patient. A comparison module detects differences between information represented by the data sets caused by progression of the disease in the joint of the patient between acquisitions. A cross-patient comparison module can compare detected differences for the patient with detected differences for at least one other patient.
24 Citations
68 Claims
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1. An orthopedic magnetic resonance imaging system, comprising:
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a source of magnetic resonance imaging data sets resulting from successive magnetic resonance imaging acquisitions from a diseased joint of a patient, a segmentation module responsive to the source of magnetic resonance imaging data sets and operative to segment surfaces in the joint based on information contained within at least one of the data sets, a registration module responsive to the source of magnetic resonance imaging data sets and operative to spatially register, in three dimensions, information represented by a first of the data sets with respect to information represented by one or more further data sets for the same patient, and a comparison module responsive to the registration module and operative to detect differences between information represented by the data sets caused by progression of the disease in the joint of the patient between acquisitions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of monitoring disease progression in a joint, comprising:
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obtaining successive images of a same joint for each of a plurality of patients, wherein at least some of the joints are diseased, segmenting joint surfaces within at least one of the images for each patient, for each of the patients, spatially registering joint features for one of the successive images with another of the successive images, detecting differences between the registered successive images for each of the individual patients, comparing the differences obtained for different ones of the patients, and storing results of the step of detecting. - View Dependent Claims (12, 13)
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14. A method of monitoring a joint, comprising:
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obtaining image data for a joint of a first patient, segmenting joint surfaces within the image data for the first patient, obtaining data from results of a step of segmenting for at least one image of a joint for at least one patient different from the first patient, and detecting differences between results of the step of segmenting joint surfaces within the image for the first patient and the data from the at least one different patient. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An orthopedic imaging system, comprising:
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at least one source of patient data including data resulting from image acquisition from at least one joint for each of a plurality of patients, a segmentation module that is responsive to the at last one source of imaging data and is operative to detect a boundary between two anatomical features of the joint, and a cross-patient comparison module responsive to the segmentation module and operative to compare data resulting from segmentation of data for one of the patients with data for another of the patients. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A data memory, comprising result data resulting from steps of:
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obtaining successive images of a same joint for each of a plurality of patients, wherein at least some of the joints are diseased, segmenting joint surfaces within at least one of the images for each patient, for each of the patients, spatially registering joint features for one of the successive images with another of the successive images, detecting differences between the registered successive images for each of the individual patients, and comparing the differences obtained for different ones of the patients.
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67. A data memory, comprising result data resulting from steps of:
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obtaining image data for a joint of a first patient, segmenting joint surfaces within the image data for the first patient, obtaining data from results of a step of segmenting for at least one image of a joint for at least one patient different from the first patient, and detecting differences between results of the step of segmenting joint surfaces within the image for the first patient and the data from the at least one different patient.
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68. An orthopedic magnetic resonance imaging system, comprising:
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a source of magnetic resonance imaging data sets resulting from successive magnetic resonance imaging acquisitions from a diseased joint of a patient, wherein the source of image data provides image data that includes cartilage surface information and bone surface information, including bone surface information for a cartilage-bone interface, a segmentation module responsive to the source of magnetic resonance imaging data sets and operative to segment surfaces in the joint based on information contained within at least one of the data sets, a registration module responsive to the source of magnetic resonance imaging data sets and operative to spatially register, in three dimensions, the bone surface information represented by a first of the data sets with respect to the bone surface information represented by one or more further data sets for the same patient, and a quantitative comparison module responsive to the registration module and operative to detect quantitative differences between information represented by the data sets caused by progression of the disease in the joint of the patient between acquisitions.
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Specification