Non-invasive breath analysis using field asymmetric ion mobility spectrometry
First Claim
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1. A system for breath analysis comprising:
- providing a breath sample;
providing an asymmetric field ion mobility spectrometer comprising;
an ionization source for ionizing the breath sample and creating ions;
an analytical gap enclosed by a housing;
an ion filter disposed in the analytical gap downstream from the ionization source, and including electrodes on an inside surface of the housing for creating an asymmetric electric field to filter the ions;
an ion flow generator including electrodes proximate but insulated with respect to the ion filter electrodes for creating an electric field transverse to the asymmetric electric field for propelling ions through the asymmetric electric field; and
an ion detector for sensing ions not filtered by the ion filter.
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Abstract
An asymmetric field ion mobility spectrometer for breath analysis and a system for analysis of a sample of breath taken from a patient.
98 Citations
30 Claims
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1. A system for breath analysis comprising:
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providing a breath sample;
providing an asymmetric field ion mobility spectrometer comprising;
an ionization source for ionizing the breath sample and creating ions;
an analytical gap enclosed by a housing;
an ion filter disposed in the analytical gap downstream from the ionization source, and including electrodes on an inside surface of the housing for creating an asymmetric electric field to filter the ions;
an ion flow generator including electrodes proximate but insulated with respect to the ion filter electrodes for creating an electric field transverse to the asymmetric electric field for propelling ions through the asymmetric electric field; and
an ion detector for sensing ions not filtered by the ion filter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. An asymmetric field ion mobility spectrometer for breath analysis comprising:
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an ionization source for ionizing a breath sample and creating ions;
an analytical gap enclosed by a housing;
an ion filter disposed in the analytical gap downstream from the ionization source, and including electrodes on an inside surface of the housing for creating an asymmetric electric field to filter the ions;
an ion flow generator including electrodes proximate but insulated with respect to the ion filter electrodes for creating an electric field transverse to the asymmetric electric field for propelling ions through the asymmetric electric field; and
an ion detector for sensing ions not filtered by the ion filter.
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29. An asymmetric field ion mobility spectrometer for breath analysis comprising:
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an ionization source for ionizing a breath sample and creating ions;
an analytical gap;
an ion filter disposed in the analytical gap downstream from the ionization source, and including a pair of spaced electrodes for creating an asymmetric electric field to filter the ions;
an ion flow generator including a plurality of spaced discrete electrodes insulated from the pair of spaced electrodes for creating an electric field transverse to the asymmetric electric field for propelling ions through the asymmetric electric field; and
an ion detector for sensing ions not filtered by the ion filter.
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30. An asymmetric field ion mobility apparatus for identification of ion species in a breath sample, the apparatus comprising:
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an ionization source for ionizing a breath sample and creating ions;
an ion filter disposed in a flow path, said flow path having a longitudinal axis for the flow of ions, said filter supplying an asymmetric filter field transverse to said longitudinal axis, said asymmetric filter field being compensated;
an ion flow generator for longitudinally propelling ions along said flow path in said compensated asymmetric filter field; and
the ion filter passing a species of said propelled ions, said species having a set of characteristics correlated with said compensated asymmetric filter field, said correlation facilitating identification of said species.
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Specification