Method and system for treating sleep apnea

• US 20050085874A1
• Filed: 10/14/2004
• Published: 04/21/2005
• Est. Priority Date: 10/17/2003
• Status: Abandoned Application

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Zilberman, Yitzhak, Davis, Ross, Cosendai, Gregoire
• Application Number:
  US10/966,629
• Publication Number:
  US 20050085874A1
• Time in Patent Office: Days
• US Class Current: 607/66
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37223 Circuits for electromagnetic coupling

Abstract

A system and method of treating sleep apnea by providing a first and a second microstimulator proximate to a first and second hypoglossal nerve (HGN) respectively and stimulating the first and second HGN for a first and second predetermined length of time. The first and second predetermined length of time may occur sequentially or concurrently. Moreover, the stimulation of the first and second HGNs may be at a sub-motor threshold afferent stimulation level or at a motor-threshold stimulation level. The stimulation of the first and second HGN may be performed in an open-loop or a closed-loop manner.

Claims

1. A method of treating sleep apnea comprising:

providing a first microstimulator proximate to a first hypoglossal nerve (HGN);

providing a second microstimulator proximate to a second HGN;

stimulating the first HGN for a first predetermined length of time; and

stimulating the second HGN for a second predetermined length of time.

2. The method of claim 1, wherein the steps of stimulating the first HGN and the second HGN are repeated.

3. The method of claim 1, wherein the first predetermined length of time and the second predetermined length of time occur sequentially.

4. The method of claim 1, wherein the first predetermined length of time and the second predetermined length of time occur concurrently.

5. The method of claim 1, wherein the first predetermined length of time is based on the first inspiratory phase of the patient.

6. The method of claim 5, wherein the second predetermined length of time is based on the second inspiratory phase of the patient.

7. A method of treating sleep apnea in a patient comprising:

monitoring the respiratory function of the patient;

determining the inspiratory pattern of the patient based on the monitoring; and

alternately stimulating a first hypoglossal nerve (HGN) and a second HGN of the patient in accordance with the inspiratory pattern.

8. The method of claim 7, wherein the stimulating comprises:

stimulating at least one HGN at a sub-motor threshold afferent stimulation level.

9. The method of claim 7, wherein the stimulating comprises:

stimulating at least one HGN at a motor-threshold level.

10. The method of claim 7, wherein the monitoring comprises:

sensing the respiratory effort of the patient with at least one sensor selected from a group consisting of;

nasal flow probe, thermocouple, pulse oxygen sensor, and force sensitive band.

11. The method of claim 7, wherein the stimulating comprises:

stimulating both hypoglossal nerves (HGN) of the patient concurrently in accordance with the inspiratory pattern.

12. The method of claim 7, wherein the first HGN is stimulated based on the first inspiratory phase of the patient.

13. The method of claim 12, wherein the second HGN is stimulated based on the second inspiratory phase of the patient.

14. A system for treating sleep apnea in a patient comprising:

a first microstimulator adapted to stimulate a first hypoglossal nerve (HGN);

a second microstimulator adapted to stimulate a second HGN;

a controller for controlling the stimulation function of the first and the second microstimulators.

15. The system of claim 14, wherein the first microstimulator is adapted to stimulate the first HGN for a first predetermined length of time and the second microstimulator is adapted to stimulate the second HGN for a second predetermined length of time.

16. The system of claim 15, wherein each of the first and the second microstimulators are less than 60 mm in longitudinal and less than 6 mm in lateral dimension.

17. The system of claim 16, wherein the first microstimulator and the second microstimulator are controlled by the controller through a wireless communication medium.

18. The system of claim 17, wherein the wireless communication medium is electromagnetic communication.

19. The system of claim 17, wherein the wireless communication medium is magnetic communication.

20. The system of claim 14, further comprising a monitoring unit for monitoring the respiratory function of the patient.

21. The system of claim 20, wherein the monitoring unit includes at least one sensor.

22. The system of claim 21, wherein the monitoring unit provides a feedback control signal to the controller for controlling the stimulation function of the first and the second microstimulators.

23. A method of treating sleep apnea in a patient comprising:

monitoring the respiratory function of the patient; and

stimulating at least one hypoglossal nerve (HGN) at sub-motor threshold afferent stimulation level.

24. The method of claim 23, wherein the stimulating is performed continuously.

25. The method of claim 23, wherein the stimulating is performed by alternately stimulating the left and the right HGN.