Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
First Claim
Patent Images
1. A polymer having a structure selected from the group consisting of:
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R(—
O—
R1), and R(—
NH—
R1)x wherein R(—
O—
)x is a polyol moiety and R(—
NH)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure;
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Abstract
Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
37 Citations
36 Claims
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1. A polymer having a structure selected from the group consisting of:
-
R(—
O—
R1), and R(—
NH—
R1)xwherein R(—
O—
)x is a polyol moiety and R(—
NH)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 36)
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10. The polymer of wherein said polyol moiety is an aliphatic or cycloaliphatic polyol moiety.
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14. A hydrophobic molecule encapsulated in a polymer, said polymer having a structure selected from the group consisting of:
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R(—
O—
R1)x and R(—
NH—
R1)xwherein R(—
O—
)x is a polyol moiety and R(—
NH—
)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure;
- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification