Treatment of disease or injury of the nervous system with FTY720
First Claim
1. A method for modulating neurogenesis in a subject comprising contacting cells in neural tissue in the subject with a composition comprising FTY720 or a derivative thereof in an amount sufficient to modulate neurogenesis.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods for modulating neurogenesis in vitro and in vivo have been disclosed. The methods comprise contacting neural stem cells with an effective amount of a FTY720 compound. The neurogenesis may involve the modulation of proliferation, differentiation, migration or survival of a non-embryonic neural stem cells or progenitor cells. Also disclosed are methods for the prevention or treatment of neurological disorders comprising administering to a subject a therapeutically effective amount of a FTY720 compound. The disorders that can be treated include various nervous system disorders.
-
Citations
38 Claims
- 1. A method for modulating neurogenesis in a subject comprising contacting cells in neural tissue in the subject with a composition comprising FTY720 or a derivative thereof in an amount sufficient to modulate neurogenesis.
- 4. A method for increasing proliferation of neural stem cells comprising contacting the cells with a composition comprising FTY720 or a derivative thereof in an amount sufficient to increase the proliferation of the cells.
- 13. A method for alleviating a symptom of a nervous system disorder in a subject comprising administering a composition comprising FTY720 or a derivative thereof to the subject in an amount sufficient to alleviate the symptom.
- 31. A method for increasing the proliferation of non-embryonic neural stem cells in vitro comprising contacting the cells with a composition comprising FTY720 or a derivative thereof in an amount sufficient to increase the proliferation of the cells.
Specification