Silicone composition for biocompatible membrane
First Claim
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1. A biocompatible membrane, the biocompatible membrane comprising a silicone composition comprising a hydrophile covalently incorporated therein, wherein the biocompatible membrane controls transport of an analyte through the membrane.
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Abstract
The present invention relates generally to biosensor materials. More specifically, this invention relates to a novel polymeric material that can be useful as a biocompatible membrane for use in biosensor applications.
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Citations
134 Claims
- 1. A biocompatible membrane, the biocompatible membrane comprising a silicone composition comprising a hydrophile covalently incorporated therein, wherein the biocompatible membrane controls transport of an analyte through the membrane.
- 27. A polymeric material, wherein the polymeric material comprises a repeating unit derived from a cyclosiloxane monomer substituted with a hydrophile, a repeating unit derived from an unsubstituted cyclosiloxane monomer, and a terminating unit derived from a polysiloxane monomer terminated with a telechelic group.
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57. A biocompatible membrane comprising a polymeric material formed from a cyclosiloxane monomer substituted with a hydrophile, an unsubstituted cyclosiloxane monomer, and a polysiloxane monomer terminated with a telechelic group.
- 58. A polymeric material, wherein the polymeric material comprises a repeating unit derived from a polyethyleneglycol-substituted octamethylcyclotetrasiloxane monomer, a repeating unit derived from an unsubstituted octamethylcyclotetrasiloxane monomer, and a repeating unit derived from a vinyldimethylsilyl-terminated polydimethylsiloxane monomer.
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65. A process for preparing a polymeric material for use in fabricating a biocompatible membrane, the process comprising the steps of:
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providing a first monomer comprising a cyclosiloxane monomer substituted with a hydrophile;
providing a second monomer comprising an unsubstituted cyclosiloxane monomer;
providing a third monomer comprising a polysiloxane monomer terminated with a telechelic group;
providing a polymerization catalyst; and
polymerizing the first monomer, the second monomer, and the third monomer, whereby a polymeric material suitable for use in fabricating a membrane is obtained. - View Dependent Claims (66, 67, 68)
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- 69. A polymeric material, the material comprising a copolymer of Formula A:
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73. A process for preparing a polymeric material for use in fabricating a biocompatible membrane, the process comprising the steps of:
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providing a first monomer comprising the Formula B;
wherein b′
is an integer of from 3 to 6 and c′
is an integer of from 1 to 30;
providing a second monomer comprising the Formula C;
wherein c′
is an integer of from 3 to 6;
providing a third monomer comprising the Formula D;
wherein d′
is an integer of from 0 to about 100;
providing a polymerization catalyst; and
polymerizing the first monomer, the second monomer, and the third monomer, whereby a polymeric material suitable for use in fabricating a membrane is obtained. - View Dependent Claims (74, 75, 76)
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- 77. A polymeric material, wherein the polymeric material comprises a repeating unit derived from a hydrophilically-substituted cyclosiloxane monomer, a repeating unit derived from an unsubstituted cyclosiloxane monomer, and a terminating unit derived from a telechelic siloxane monomer.
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103. A method for preparing a biocompatible membrane, the method comprising:
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providing a polymeric material, wherein the polymeric material comprises a repeating unit derived from a cyclosiloxane monomer substituted with a hydrophile, a repeating unit derived from an unsubstituted cyclosiloxane monomer, and a terminating unit derived from a polysiloxane monomer terminated with a telechelic group;
mixing the polymeric material with a diluent, whereby a solution or dispersion is obtained;
forming the solution or dispersion into a film; and
curing the film, wherein the cured film comprises a biocompatible membrane. - View Dependent Claims (104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134)
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Specification