Aerosolized active agent delivery
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Abstract
The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at an inspiratory flow rate of less than 17 liters per minute. The bioavailability of the active agent was found to increase at these flow rates when compared to inspiratory flow rates of 17 liters per minute or more.
151 Citations
52 Claims
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1-22. -22. (cancelled)
- 23. A device for increasing the bioavailability of an aerosolized active agent, said device comprising a flow restrictor for limiting the flow of an aerosolized active agent formulation to a human patient to less than 17 liters per minute, wherein the device is adapted to aerosolize the active agent formulation and wherein the active agent formulation is (i) a powder, (ii) a solution, suspension, or slurry that may be nebulized, or (iii) suspended or dissolved in a propellant.
- 33. A device for delivering an aerosolized active agent to the lungs of a human patient, wherein said device is adapted to deliver an aerosolized active agent formulation at an inspiratory flow rate of less than 17 liters per minute, wherein the device is adapted to aerosolize the active agent formulation and wherein the active agent formulation is (i) a powder, (ii) a solution, suspension, or slurry that may be nebulized, or (iii) suspended or dissolved in a propellant.
- 38. A device for delivering aerosolized insulin to the lungs of a human patient, wherein said device comprises a flow restrictor to restrict an inspiratory flow rate of an aerosolized insulin formulation to less than 17 liters per minute and wherein the device is adapted to aerosolize the insulin.
- 42. A device for delivering an aerosolized active agent to the lungs of a human patient, wherein said device comprises one or more orifices sized so that au aerosolized active agent formulation may be delivered at an inspiratory flow rate of less than 17 liters per minute, wherein the device is adapted to aerosolize the active agent formulation and wherein the active agent formulation is (i) a powder, (ii) a solution, suspension, or slurry that may be nebulized, or (iii) suspended or dissolved in a propellant.
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47. A device for delivering an aerosolized active agent to the lungs of a human patient, said device comprising:
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a chamber in flow communication with a mouthpiece;
means for aerosolizing the active agent; and
means for limiting an inspiratory flow rate through the mouthpiece to less than 17 liters per minute, whereby an aerosolized active agent formulation in the chamber may be delivered to the human patient, the active agent formulation being (i) a powder, (ii) a solution, suspension, or slurry that may be nebulized, or (iii) suspended or dissolved in a propellant. - View Dependent Claims (48, 49, 50, 51, 52)
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Specification