Distal protection device with electrospun polymer fiber matrix

• US 20050090858A1
• Filed: 11/23/2004
• Published: 04/28/2005
• Est. Priority Date: 01/25/2001
• Status: Abandoned Application

• Current Assignee: ev3, Inc. (Medtronic Plc)
• Original Assignee: ev3, Inc. (Medtronic Plc)
• Inventors: Pavlovic, Jennifer L.
• Application Number:
  US10/996,277
• Publication Number:
  US 20050090858A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2/0105 Open ended, i.e. legs gathered only at one side
• CPC Class Codes: A61F 2/0108 Both ends closed, i.e. legs gathered at both ends
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/0008 elliptical or oval
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped

Abstract

The present invention relates to a protection device for use in a lumen of a patient'"'"'s body. The protection device has a fiber matrix electrospun about an expandable and collapsible wire frame. In the collapsed configuration the protection device may be advanced within a lumen. In the expanded configuration, the protection device is able to engage the walls of the lumen wherein, the fiber matrix forms a plurality of pores for preventing the passage of particulate material and allow fluid to flow through.

Claims

1-31. -31. (canceled).

32. A method for making a distal protection device for filtering particulate from a fluid in a lumen of a patient'"'"'s body, comprising:

forming a wire frame by orienting wires to define a periphery; and

electrospinning fibers onto the wire frame to form a fiber matrix shaped to the periphery of the wire frame, the wire frame and fiber matrix together forming a filter, the filter having a collapsed configuration prior to deployment in the lumen and an expanded configuration after deployment in the lumen.

33. A method of claim 32 including forming the fiber matrix by individually applying fibers onto the wire frame.

34. A method of claim 32 including forming the fiber matrix by applying fibers in a flowable state onto the wire frame.

35. A method of claim 32 including forming the fiber matrix by applying a single strand of fiber onto the wire frame.

36. A method of claim 32 including forming the fiber matrix in a regular woven pattern.

37. A method of claim 32 including forming the fiber matrix in a random woven pattern.

38. A method of claim 32 including forming the wire frame by braiding the wires.

39. A method of claim 32 including treating a component selected from the filter, the wire frame, the fiber matrix and combinations thereof to prevent passage of particulate and fluid.

40. A method of claim 32 including orienting the fiber matrix to a distal side of the wire frame.

41. A method of claim 32 including orienting the fiber matrix to a proximal side of the wire frame.

42. A method of claim 32 including interweaving fibers through the wire frame to form the fiber matrix.

43. A method of claim 32 including treating a component selected from the filter, the wire frame, the fiber matrix and combinations thereof to prevent occlusion of the pores.

44. A method of claim 32, wherein the filter has pores of about 100 microns and a percent open area of about 80%.

45. A method of claim 32, wherein the wires have a first diameter and fibers of the fiber matrix have a lesser diameter.

46. A method of claim 32, wherein the wires are selected from metal or polymers.

47. A method of claim 46, wherein the polymers are selected from nylons, Teflon, Tefzel, polyurethanes, shape memory polymers and combinations thereof.

48. A method of claim 46, wherein the metals are selected from elgiloy, MP35N, spring steel, stainless steel, titanium, a shape memory metal alloy and combinations thereof.

49. A method of claim 32, wherein fibers of the fiber matrix have a diameter of about 8 to 10 microns and the fiber matrix has a pore size of about 100 microns.

50. A method of claim 32, wherein fibers of the fiber matrix are selected from polyurethane, nylon, PEBAX, silicone, a flexible polymer suitable for electrospinning, polylactic acid and combinations thereof.

51. A method of claim 32, wherein the wires have a diameter of about 0.001 to 0.005 inches.

52. A method of claim 32, and further comprising positioning the filter along a distal region of a guidewire.

53. A method of claim 52, wherein the filter has a collapsed configuration and an expanded configuration, wherein:

the filter in the collapsed configuration is collapsed toward the guidewire; and

the filter in the expanded configuration is expanded outward from the guidewire to engage a wall defining the lumen.

54. A method according to claim 32, wherein the wire frame and the fiber matrix together define a plurality of pores constructed and arranged to prevent passage of particulate while allowing passage of fluid therethrough.