Artificial organ

• US 20050095229A1
• Filed: 12/02/2004
• Published: 05/05/2005
• Est. Priority Date: 03/07/2001
• Status: Abandoned Application

• Current Assignee: Biomed Solutions, LLC
• Original Assignee: Biomed Solutions, LLC
• Inventors: Weiner, Michael L., Connelly, Patrick
• Application Number:
  US11/003,562
• Publication Number:
  US 20050095229A1
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150274 Manufacture or production processes or steps for blood sampling devices
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3689 by biological cells
• CPC Class Codes: A61M 1/38 : Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: G01N 15/10 : Investigating individual particles
• CPC Class Codes: G01N 15/1456 : without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
• CPC Class Codes: G01N 15/149 : specially adapted for sorting particles, e.g. by their size or optical properties
• CPC Class Codes: G01N 2015/1006 : for cytology

Abstract

Disclosed is an artificial organ comprised of a conduit adapted to be connected to a blood pool, the blood pool comprising a first analyte and a second analyte; a cell culture media comprised of a first cell culture and a second cell culture, each of which are capable of producing the first analyte and said second analyte respectively; and a controller that is capable of measuring a concentration of the first and second analyte in the blood pool, and delivering a specified amount of the first and second analyte from the cell culture media to the blood pool, and delivering a specified amount of the second analyte from the cell culture media to the blood pool.

Claims

1. An artificial organ comprising:

a. a conduit adapted to be connected to a blood pool, said blood pool comprising a first analyte and a second analyte;

b. a cell culture media comprised of a first cell culture and a second cell culture, said first cell culture being capable of producing said first analyte and said second cell culture being capable of producing said said second analyte; and

c. a controller comprised of means for measuring a concentration of said first analyte in said blood pool, means for measuring a concentration of said second analyte in said blood pool, means for delivering a specified amount of said first analyte from said cell culture media to said blood pool, and means for delivering a specified amount of said second analyte from said cell culture media to said blood pool.

2. The artificial organ as recited in claim 1, wherein said first analyte and said second analyte are selected from the group consisting of insulin, glucagons, somatostatin, and combinations thereof.

3. The artificial organ as recited in claim 1, wherein said blood pool is further comprised of a third analyte, said cell culture media is further comprised of a third cell culture media which produces said third analyte, and said controller is further comprised of means for measuring a concentration of said third analyte in said blood pool, and means for delivering a specified amount of said third analyte from said cull culture media to said blood pool.

4. The artificial organ as recited in claim 3, wherein said first analyte, said second analyte, and said third analyte are selected from the group consisting of insulin, glucagons, somatostatin, and combinations thereof.

5. The artificial organ as recited in claim 4, wherein said controller is an Application Specific Integrated Circuit controller.

6. The artificial organ as recited in claim 4, wherein said cell culture media has a pH between about 7.1 and about 7.4.

7. The artificial organ as recited in claim 4, wherein said means for delivering a specified amount of said first analyte from said cell culture media to said blood pool further comprises a filter for purifying said first analyte.

8. The artificial organ as recited in claim 4, wherein said artificial organ is implantable within a living organism.

9. The artificial organ as recited in claim 8, wherein said artificial organ is hermetically sealed.

10. The artificial organ as recited in claim 1, further comprising a reservoir containing at least a portion of said blood pool.

11. A process for adjusting the concentration of an analyte in a living organism comprising the step of disposing the artificial organ as recited in claim 8 within a living organism, wherein said blood pool is comprised of blood from said living organism.

12. A process for adjusting the concentration of an analyte in a living organism comprising the step of connecting the artificial organ as recited in claim 4 to a blood vessel of a living organism, wherein said blood pool is comprised of blood from said living organism and said artificial organ is disposed outside of said living organism.

13. The process as recited in claim 12, wherein said blood vessel is selected from the group consisting of an artery, a vein, and combinations thereof.

14. An artificial organ comprised of:

a. a conduit adapted to be connected to a blood pool, said blood pool comprising a first analyte and a second analyte selected from the group consisting of insulin, glucagon, somatostatin, and combinations thereof;

b. a cell culture media comprised of a first cell culture which produces said first analyte; and

c. a controller comprised of means for measuring a concentration of said first analyte in said blood pool, thus producing a first measured concentration, and means for delivering a specified amount of said first analyte from said cell culture media to said blood pool.

15. The artificial organ as recited in claim 14, wherein said controller determines said specified amount of said first analyte based on said first measured concentration.

16. The artificial organ as recited in claim 15, wherein said blood pool is further comprised of a second analyte, said cell culture media is further comprised of a second cell culture media which produces said second analyte, and said controller is further comprised of means for measuring a concentration of said second analyte in said blood pool, thus producing a second measured concentration, and means for delivering a specified amount of said second analyte from said cull culture media to said blood pool.

17. The artificial organ as recited in claim 16, wherein said controller determines said specified amount of said second analyte based on said second measured concentration.

18. The artificial organ as recited in claim 17, wherein said blood pool is further comprised of a third analyte, said cell culture media is further comprised of a third cell culture media which produces said third analyte, and said controller is further comprised of means for measuring a concentration of said third analyte in said blood pool, thus producing a third measured concentration, and means for delivering a specified amount of said third analyte from said cull culture media to said blood pool.

19. The artificial organ as recited in claim 18, wherein said controller determines said specified amount of said third analyte based on said third measured concentration.

20. The artificial organ as recited in claim 15 further comprising a reservoir containing at least a portion of said blood pool.