Antimicrobial topical compositions for treatment of rosacea
First Claim
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1. A method for treating rosacea in a patient, comprising:
- topically administering to a patient in need thereof a storage-stable topical composition in an amount effective to treat said rosacea, wherein said topical composition comprises;
a mixture of an active ingredient comprising an antimicrobial agent or a pharmaceutically acceptable salt thereof, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier, wherein said active ingredient maintains a concentration of degradation product(s) that enhances the effectiveness of the topical composition in treating rosacea.
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Abstract
Methods of treating rosacea using a storage-stable topical composition comprising a mixture of an antimicrobial active ingredient, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier. These methods also contemplate the reduction or elimination of Demodex folliculorum organisms from affected skin areas, thereby reducing clinical signs of rosacea potentially due to allergic and vasomotor responses of the body to the organism in susceptible persons.
123 Citations
64 Claims
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1. A method for treating rosacea in a patient, comprising:
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topically administering to a patient in need thereof a storage-stable topical composition in an amount effective to treat said rosacea, wherein said topical composition comprises;
a mixture of an active ingredient comprising an antimicrobial agent or a pharmaceutically acceptable salt thereof, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier, wherein said active ingredient maintains a concentration of degradation product(s) that enhances the effectiveness of the topical composition in treating rosacea. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for reducing or eliminating mite organisms that cause rosacea in a patient, comprising:
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topically administering to skin of a patient infected with said mite organisms a storage-stable topical composition in an amount effective to reduce or eliminate said mite organisms, wherein said topical composition comprises;
a mixture of an active ingredient comprising an antimicrobial agent or a pharmaceutically acceptable salt thereof, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier, wherein said active ingredient maintains a concentration of degradation product(s) that enhances the effectiveness of the topical composition in reducing or eliminating said mite organisms. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A method for treating rosacea in a patient having sensitive skin, comprising:
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topically administering to sensitive skin area, irritated skin areas, or inflamed skin areas of a patient in need thereof a storage-stable topical composition in an amount effective to treat said rosacea, wherein said topical composition comprises;
a mixture of an active ingredient comprising an antimicrobial agent or a pharmaceutically acceptable salt thereof, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier, wherein said active ingredient maintains a concentration of degradation product(s) that enhances the effectiveness of the topical composition in treating rosacea. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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62. A method for treating rosacea in a patient, comprising:
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topically administering to a patient in need thereof a storage-stable topical composition in an amount effective to treat said rosacea, wherein said topical composition comprises;
a mixture of an active ingredient comprising an antimicrobial agent or a pharmaceutically acceptable salt thereof, sufficient amounts of at least one pH modifier to provide the topical composition with an overall pH of about 3.0 to about 8.0, and a pharmaceutically acceptable carrier, wherein said active ingredient maintains a concentration of degradation product(s) that enhances the effectiveness of the topical composition in treating rosacea;
and wherein said topical composition is administered concomitantly or sequentially with an additional active agent effective to treat said rosacea. - View Dependent Claims (63, 64)
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Specification