Apparatus comprising polymers
First Claim
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1. A method of identifying at least one polymer for binding with a receptor comprising the steps of:
- a) on a substrate, said substrate comprising polymers immobilized on a surface of said substrate, said polymers comprising a photoremovable protective group, irradiating a first region of said substrate without irradiating a second region of said substrate to remove said protecting group from said polymers in said first region; and
b) contacting said substrate with a first monomer to couple said monomer to said polymer in said first region, forming a first polymer on said substrate in said first region that is different from 0 said polymer in said second region.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
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7 Claims
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1. A method of identifying at least one polymer for binding with a receptor comprising the steps of:
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a) on a substrate, said substrate comprising polymers immobilized on a surface of said substrate, said polymers comprising a photoremovable protective group, irradiating a first region of said substrate without irradiating a second region of said substrate to remove said protecting group from said polymers in said first region; and
b) contacting said substrate with a first monomer to couple said monomer to said polymer in said first region, forming a first polymer on said substrate in said first region that is different from 0 said polymer in said second region. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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