Compositions and methods of formulation for enteral formulas containing sialic acid

• US 20050096295A1
• Filed: 10/13/2004
• Published: 05/05/2005
• Est. Priority Date: 04/14/2003
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Locniskar, Mary Frances, McMahon, Robert J., Anthony, Joshua C., Rumsey, Steven Charles, Wantanagorn, Ratchapong
• Granted Patent: US 7,951,410 B2
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A23C 9/1307 Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
• CPC Class Codes: A23C 9/20 Dietetic milk products not covered by groups A23C9/12 - A23C9/18
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/06 Amino acid
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/187 Eicosapentaenoic acid
• CPC Class Codes: A23V 2250/5424 Dairy protein
• CPC Class Codes: A23V 2250/5438 Sialic acid, glycomacroprotein
• CPC Class Codes: A23V 2250/70 Vitamins

Abstract

A nutritionally complete infant formula containing sialic acid derived from one or a number of nutritionally appropriate sources is described.

Claims

1. An infant formula comprising cGMP having an enhanced concentration of sialic acid.

2. The infant formula according to claim 1, having a sialic acid level of at least about 200 mg/liter.

3. The infant formula according to claim 1, having a sialic acid level of at least about 250 mg/liter.

4. The infant formula according to claim 1, having a sialic acid level of at least about 300 mg/liter.

5. The infant formula according to claim 1, having a sialic acid level of at least about 400 mg/liter.

6. The infant formula according to claim 1, having a sialic acid level of at least about 600 mg/liter.

7. The infant formula according to claim 1, having a total protein content of between 12 and 16 grams/liter of which no more than 40% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

8. The infant formula according to claim 1, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

9. The infant formula according to claim 1, having a total protein content of between 13 and 15 grams/liter of which no more than 15% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

10. The infant formula according to claim 3, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

11. The infant formula according to claim 4, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

12. The infant formula according to claim 5, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

13. The infant formula according to claim 1, wherein the cGMP having an enhanced concentration of sialic acid comprises high-sialic acid cGMP with reduced threonine.

14. The infant formula according to claim 13, having a sialic acid level of at least about 250 mg/liter.

15. The infant formula according to claim 13, having a sialic acid level of at least about 300 mg/liter.

16. The infant formula according to claim 13, having a sialic acid level of at least about 400 mg/liter.

17. The infant formula according to claim 13, having a sialic acid level of at least about 600 mg/liter.

18. The infant formula according to claim 13, having a total protein content of between 12 and 16 grams/liter of which no more than 40% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

19. The infant formula according to claim 13, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

20. The infant formula according to claim 13, having a total protein content of between 13 and 15 grams/liter of which no more than 15% by weight is provided by a cGMP having an enhanced concentration of sialic acid.

21. The infant formula according to claim 14, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid and having a threonine content of not over 10 grams/16 grams nitrogen.

22. The infant formula according to claim 15, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid and having a threonine content of not over 7 grams/16 grams nitrogen.

23. The infant formula according to claim 16, having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a cGMP having an enhanced concentration of sialic acid and having a threonine content of not over 4 grams/16 grams nitrogen.

24. The infant formula according to claim 13, having a total protein content of about 14 grams/liter of which not over 4% by weight is threonine and having a sialic acid content of at least 400 mg/liter.

25. A method of producing an infant formula comprising intermixing a cGMP having an enhanced concentration of sialic acid with sources of protein, carbohydrate and lipid sufficient to provide a nutritionally complete formula.