Compositions and methods for treatment of nervous system disorders
First Claim
1. A formulation comprising oxcarbazepine and an antidepressant, wherein said antidepressant is selected from the group consisting of bupropion, bupropion derivatives and bupropion metabolites.
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Abstract
The present invention contemplates compositions and methods to treat patients having a nervous system disorder with a formulation comprising an anticonvulsant and a neuroactive modulator. Also described is a method to predict the probability of a significant recovery when a treating an individual patient having a nervous system disorder with a formulation comprising an anticonvulsant and a neuroactive modulator. Specifically, methods for predicting patient prognosis include, but are not limited to, quantitative electroencephalography, psychometric test batteries, biological indicators, brain metabolic indicators, genotype profiles, neuroimaging, objective test measurements and multi-modalities. The present invention also discloses a device providing an organized dispensation of the above formulations such that the patient or medical personnel may easily and accurately decrease the daily dosage of a third drug and increase the daily dosage of a formulation comprising an anticonvulsant and a neuroactive modulator.
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Citations
16 Claims
- 1. A formulation comprising oxcarbazepine and an antidepressant, wherein said antidepressant is selected from the group consisting of bupropion, bupropion derivatives and bupropion metabolites.
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4. A method of treatment, comprising:
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a) providing a patient exhibiting at least one symptom of a nervous system disorder, and b) administering to the patient a formulation comprising oxcarbazepine and bupropion such that at least one symptom of said nervous system disorder is reduced. - View Dependent Claims (5, 6, 7, 8)
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9. A method of treatment, comprising:
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a) providing a patient exhibiting at least one symptom of a nervous system disorder and is being treated with a dose of a third drug, wherein said patient is non-remissive; and
b) administering to said patient a formulation comprising a dose of oxcarbazepine and a dose of bupropion such that at least one symptom of said nervous system disorder is reduced. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification