Minimally-invasive system and method for monitoring analyte levels
First Claim
1. A device for detecting at least one analyte in a patient, comprising:
- at least one active electrode, said active electrode having a length such that said active electrode is adapted to pass through the stratum corneum to a depth sufficient to access said analyte to enable the electrochemical detection of said analyte; and
at least one auxiliary electrode configured to at least partially surround said active electrode, and adapted to contact patient'"'"'s skin when the device is placed against said patient.
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Abstract
A minimally-invasive analyte detecting device and method for using the same. The system and method employ a device having an active electrode optionally coated with a substance, and a counter-electrode that is configured at least partially surround the active electrode. The configuration of the auxiliary electrode and active electrode improves the current flow through the device and increases the sensitivity of the device. When the device is placed against the patient'"'"'s skin, the active electrode is adapted to enter through the stratum corneum of a patient to a depth less than a depth in the dermis at which nerve endings reside. An electric potential is applied to the active electrode and the analyte level is determined based on the amount of current or charge flowing through the device.
381 Citations
65 Claims
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1. A device for detecting at least one analyte in a patient, comprising:
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at least one active electrode, said active electrode having a length such that said active electrode is adapted to pass through the stratum corneum to a depth sufficient to access said analyte to enable the electrochemical detection of said analyte; and
at least one auxiliary electrode configured to at least partially surround said active electrode, and adapted to contact patient'"'"'s skin when the device is placed against said patient. - View Dependent Claims (2, 3, 4, 5, 7, 11, 12, 13, 14, 15, 18, 19)
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6. (canceled)
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24. A device for detecting at least one analyte in a patient, comprising:
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at least one active electrode having a length such that said active electrode is adapted to pass through the stratum corneum of said patient to a depth sufficient to access said analyte; and
at least one substance adjacent to at least a portion of said active electrode capable of reacting with at least one analyte to produce at least one electrochemically active product; and
an auxiliary electrode configured to at least partially surround said active electrode, and adapted to contact said patient'"'"'s skin when the device is placed against said patient. - View Dependent Claims (25, 26, 27, 28, 29, 31, 35, 36, 37, 38, 39)
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30. (canceled)
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45. A method for detecting an electrochemically active component in a patient, comprising:
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placing a device against the skin of said patient, said device having at least one active electrode, said active electrode having a length adapted to pass through the stratum corneum of said patient to a depth sufficient to access said analyte, said device having at least one auxiliary electrode configured to at least partially surround said active electrode, said auxiliary electrode being adapted to contact said patient'"'"'s skin when said device is placed against said patient;
applying a potential to said active electrode; and
,measuring current or charge from the electrochemical reaction of said electrochemically active component and said active electrode. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method for detecting a component in a patient, comprising:
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placing a device against the skin of said patient, said device having at least one active electrode, said active electrode having a length adapted to pass through the stratum corneum of said patient to a depth sufficient to access said analyte, said active electrode having at least one substance adjacent to at least a portion of said active electrode to enable said component to react with said substance to produce at least one electrochemically active product, said device having at least one auxiliary electrode configured to at least partially surround said active electrode, said auxiliary electrode being adapted to contact said patient'"'"'s skin when said device is placed against said patient;
applying a potential to said active electrode; and
measuring current based on said reaction of said electrochemically active component in said patient and said substance. - View Dependent Claims (62, 63, 64, 65)
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Specification