Stimulation for delivery of molecular therapy
First Claim
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1. A subthreshold pulse generator comprising:
- a.) a power supply; and
b a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissues wherein the subthreshold stimulus is less than or equal to about 1 volt.
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Abstract
The present invention provides a novel stimulatory device for the controlled production of angiogenic growth factors. More specifically, the present invention provides a subthreshold pulse generator for the local production of vascular endothelial growth factor.
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Citations
68 Claims
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1. A subthreshold pulse generator comprising:
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a.) a power supply; and
b a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissues wherein the subthreshold stimulus is less than or equal to about 1 volt. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 52, 66, 67, 68)
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50. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked with targeted mammalian cells or tissues wherein the subthreshold pulse generator comprises
(a) a power supply; - and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the threshold stimulus is less than or equal to about 1 volt.
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51. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to the tissue for acute subthreshold stimulation therapy to improve angiogenesis;
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt.
- wherein the subthreshold pulse generator comprises
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53. A method of increasing vascularization in a target tissue comprising providing subthreshold stimulatory pulses to the targeted muscle tissue using a subthreshold pulse generator:
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt.
- wherein the subthreshold pulse generator comprises
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54. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to vascular muscle tissue using a subthreshold pulse generator;
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt.
- wherein the subthreshold pulse generator comprises
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55. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to heart muscle tissue using a subthreshold pulse generator;
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt.
- wherein the subthreshold pulse generator comprises
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56. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to skeletal muscle tissue using a subthreshold pulse generator;
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt.
- wherein the subthreshold pulse generator comprises
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57. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to a muscle tissue for subthreshold stimulation therapy using a subthreshold pulse generator;
- wherein the subthreshold pulse generator comprises
(a) a power supply; and
(b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue wherein the subthreshold stimulus is less than or equal to about 1 volt. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65)
- wherein the subthreshold pulse generator comprises
Specification