Hydrophilic coated medical device
First Claim
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1. A medical device for at least partial implantation in a patient, comprising:
- an elongated member;
a therapeutic agent disposed on an exterior of the elongated member; and
a hydrophilic coating disposed on the elongated member.
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Abstract
A medical device comprises a main body, a therapeutic agent and a radiation-curable hydrophilic coating. The hydrophilic coating allows for easy insertion of medical devices, which may include catheters, cannulae, stents, wire guides, and the like. The medical device may include more than one therapeutic agent.
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Citations
25 Claims
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1. A medical device for at least partial implantation in a patient, comprising:
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an elongated member;
a therapeutic agent disposed on an exterior of the elongated member; and
a hydrophilic coating disposed on the elongated member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of making a medical device, comprising:
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forming a tubular member defining at least one lumen;
coating at least an exterior surface of the tubular member with a radiation-curable coating; and
curing the coating. - View Dependent Claims (13, 14, 15)
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16. A medical device for at least partial implantation in a patient, comprising:
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a tube member defining a lumen;
a mixture of rifampin and minocycline distributed throughout at least a portion of the tube; and
a radiation-curable hydrophilic coating on an exterior of the device.
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17. A method of making a medical device, the method comprising:
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forming a tubular member defining at least one lumen;
coating at least an exterior surface of the tubular member with a radiation-curable coating; and
curing the coating, wherein the coating further comprises a reagent useful as a surface coating agent, the reagent having a nonpolymeric core molecule comprising an aromatic group, the core molecule having attached thereto, either directly or indirectly, one or more substituents comprising negatively charged groups, and two or more photoreactive species attached to the core molecule through one or more spacer groups, wherein the negatively charged groups are independently selected from salts of organic acids, the organic acids are selected from sulfonic acid, carboxylic acid, and phosphoric acid, the aromatic group is a benzene radical, the photoreactive species are aryl ketones that may be the same or may be different, and the spacer groups each independently comprise a radical of the formula —
O—
(CH2)n—
, wherein n is a whole number equal to at least one. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
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Specification