Hydrophilic coated medical device

• US 20050100580A1
• Filed: 10/14/2004
• Published: 05/12/2005
• Est. Priority Date: 10/14/2003
• Status: Abandoned Application

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Osborne, Thomas A., Gingles, Bruce, Urbanski, Jason, Hoffa, Andrew
• Application Number:
  US10/965,584
• Publication Number:
  US 20050100580A1
• Time in Patent Office: Days
• US Class Current: 424/424
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A medical device comprises a main body, a therapeutic agent and a radiation-curable hydrophilic coating. The hydrophilic coating allows for easy insertion of medical devices, which may include catheters, cannulae, stents, wire guides, and the like. The medical device may include more than one therapeutic agent.

Claims

1. A medical device for at least partial implantation in a patient, comprising:

an elongated member;

a therapeutic agent disposed on an exterior of the elongated member; and

a hydrophilic coating disposed on the elongated member.

2. The medical device of claim 1, wherein the hydrophilic coating at least partly covers the therapeutic agent.

3. The medical device of claim 1, wherein the hydrophilic coating is intermingled with the agent.

4. The medical device of claim 1, wherein the hydrophilic coating is radiation-curable, UV-curable, photoimmobilizable, or photoreactive.

5. The medical device of claim 1, wherein the hydrophilic coating is a PhotoLink®

radiation-curable coating.

6. The medical device of claim 1, wherein the medical device is a catheter.

7. The medical device of claim 1, wherein the therapeutic agent is an anticoagulant, an antithrombotic, a thrombolytic, a fibrinolytic, an antiproliferative, an antibacterial, or an antibiotic agent.

8. The medical device of claim 1, wherein the therapeutic agent comprises minocycline or rifampin.

9. The medical device of claim 1, wherein the therapeutic agent comprises at least two therapeutic agents disposed on the exterior.

10. The medical device of claim 9, wherein the therapeutic agents comprise rifampin and minocycline.

11. The medical device of claim 4, wherein the hydrophilic coating comprises a reagent useful as a surface coating agent, the reagent having a nonpolymeric core molecule comprising an aromatic group, the core molecule having attached thereto, either directly or indirectly, one or more substituents comprising negatively charged groups, and two or more photoreactive species attached to the core molecule through one or more spacer groups, wherein the negatively charged groups are independently selected from salts of organic acids, the organic acids are selected from sulfonic acid, carboxylic acid, and phosphoric acid, the aromatic group is a benzene radical, the photoreactive species are independently aryl ketones, and the spacer groups each independently comprise a radical of the formula —

O—

(CH₂)_n—

wherein n is a whole number equal to at least one.

12. A method of making a medical device, comprising:

forming a tubular member defining at least one lumen;

coating at least an exterior surface of the tubular member with a radiation-curable coating; and

curing the coating.

13. The method of claim 12, wherein the radiation-curable coating is a PhotoLink®

coating.

14. The method of claim 12, further comprising coating the exterior of the tubular member with at least one therapeutic agent before the step of coating the exterior surface.

15. The method of claim 12, wherein the tubular member is formed with a therapeutic agent is dispersed within the tubular member.

16. A medical device for at least partial implantation in a patient, comprising:

a tube member defining a lumen;

a mixture of rifampin and minocycline distributed throughout at least a portion of the tube; and

a radiation-curable hydrophilic coating on an exterior of the device.

17. A method of making a medical device, the method comprising:

forming a tubular member defining at least one lumen;

coating at least an exterior surface of the tubular member with a radiation-curable coating; and

curing the coating, wherein the coating further comprises a reagent useful as a surface coating agent, the reagent having a nonpolymeric core molecule comprising an aromatic group, the core molecule having attached thereto, either directly or indirectly, one or more substituents comprising negatively charged groups, and two or more photoreactive species attached to the core molecule through one or more spacer groups, wherein the negatively charged groups are independently selected from salts of organic acids, the organic acids are selected from sulfonic acid, carboxylic acid, and phosphoric acid, the aromatic group is a benzene radical, the photoreactive species are aryl ketones that may be the same or may be different, and the spacer groups each independently comprise a radical of the formula —

O—

(CH₂)_n—

, wherein n is a whole number equal to at least one.

18. The reagent of claim 17 wherein the reagent is of the formula

19. The reagent of claim 18 wherein the Y group comprises a benzene radical.

20. The reagent of claim 19 wherein the charged groups Z are selected from sulfonic acid, carboxylic acid, and phosphoric acid.

21. The reagent of claim 19 wherein the photoreactive species of X₁ and X₂ are aryl ketones, and X₁ and X₂ may be the same or may be different.

22. The reagent of claim 21 wherein the aryl ketones are selected from the group consisting of acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.

23. The reagent of claim 17 wherein each aryl ketone is selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives, and the aryl ketones may be the same or may be different.

24. The reagent of claim 17 wherein the spacer groups each independently comprise a radical of the formula —

(C₂H₄O)_m—

C₂H₄O—

wherein m is a whole number equal to at least one.

25. The medical device of claim 17, wherein the medical device is selected from the group consisting of a wire guide, a catheter, a stent, a cannula, a venous access catheter, a central venous access catheter, a binary drainage catheter, a suprapubic urinary drainage catheter, a gastrostomy catheter, a dialysis catheter, and an arterial catheter.