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Genomics applications for modified OLIGO nucleotides

  • US 20050100921A1
  • Filed: 09/26/2003
  • Published: 05/12/2005
  • Est. Priority Date: 03/27/2001
  • Status: Active Grant
First Claim
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1. A method for producing a stabilized double D loop at a target sequence within a double-stranded nucleic acid, the method comprising:

  • contacting the double-stranded nucleic acid with a first oligonucleotide and a second oligonucleotide, said first and second oligonucleotides having at least a region of complementarity therebetween, wherein said first oligonucleotide is bound by a recombinase and has a region that is substantially complementary in sequence to a first strand of said target, and said second oligonucleotide is not substantially bound by a recombinase and has a region that is substantially complementary in sequence to a second strand of said target.

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