Compositions and methods for treating a posterior segment of an eye
First Claim
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1. A composition useful for injection into a posterior segment of an eye of a human or animal comprising:
- a corticosteroid component present in a therapeutically effective amount, the corticosteroid component being present in a plurality of particles;
a viscosity inducing component in an amount effective in increasing the viscosity of the composition; and
an aqueous carrier component, the composition having a viscosity of at least about 10 cps at a shear rate of 0.1/second and being effectively injectable into a posterior segment of an eye of a human or animal.
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Abstract
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
307 Citations
62 Claims
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1. A composition useful for injection into a posterior segment of an eye of a human or animal comprising:
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a corticosteroid component present in a therapeutically effective amount, the corticosteroid component being present in a plurality of particles;
a viscosity inducing component in an amount effective in increasing the viscosity of the composition; and
an aqueous carrier component, the composition having a viscosity of at least about 10 cps at a shear rate of 0.1/second and being effectively injectable into a posterior segment of an eye of a human or animal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A composition useful for injection into a posterior segment of an eye of a human or animal comprising:
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a corticosteroid component present in a therapeutic effect amount, the corticosteroid component being present in a plurality of particles;
a viscosity inducing component in an amount effective in increasing the viscosity of the composition; and
an aqueous carrier component, the particles being substantially uniformly suspended in the composition and remaining substantially uniformly suspended in the composition for at least about 1 week without requiring resuspension processing. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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Current AssigneeAllergan, Inc. (Canada) (Abbvie Incorporated)
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Original AssigneeAllergan, Inc. (Canada) (Abbvie Incorporated)
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InventorsWhitcup, Scott M., Chang, James N., Trogden, John T., Lyons, Robert T.
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Application NumberUS10/966,764Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/179CPC Class CodesA61K 31/573 substituted in position 21,...A61K 31/58 containing heterocyclic rin...A61K 47/36 Polysaccharides; Derivative...A61K 9/0048 Eye, e.g. artificial tearsA61P 27/02 Ophthalmic agentsA61P 31/00 Antiinfectives, i.e. antibi...A61P 31/04 Antibacterial agentsA61P 31/06 for tuberculosisA61P 31/12 AntiviralsA61P 31/18 for HIVA61P 33/00 Antiparasitic agentsA61P 33/02 Antiprotozoals, e.g. for le...A61P 35/00 Antineoplastic agentsA61P 35/04 specific for metastasisA61P 41/00 Drugs used in surgical meth...A61P 5/40 Mineralocorticosteroids, e....A61P 9/10 for treating ischaemic or a...
