Method and system for non-invasive determination of blood-related parameters
First Claim
1. A non-invasive method for use in determining at least one desired characteristic of blood of a patient, the method comprising:
- (a) creating a condition of artificial blood kinetics at a measurement location in a patient'"'"'s blood perfused fleshy medium and maintaining this condition for a certain time period;
(b) applying an external electromagnetic field to the measurement location;
(c) detecting a time response of the medium from at least a portion of the measurement location to said external electromagnetic field; and
(d) generating measured data indicative of time evolutions of the response of the medium over at least a part of said certain time period;
wherein the response to said external electromagnetic field includes at least one of the following;
an acoustic response to illuminating incident light having a wavelength in a range where the scattering properties of blood are sensitive to light radiation, and an impedance of the portion of the medium.
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Accused Products
Abstract
A method and system for measuring time variations of a response of a blood perfused fleshy medium to an external electromagnetic field is provided. The response of the medium to the external electromagnetic field can be a photo-acoustic signal, obtained in response to the exciting light, and/or impedance of the medium, in response to the applied ac electromagnetic field. Measurements of the time variations of the response of the medium are carried out when the condition of artificial kinetics is created and maintained over a certain time period by applying primary over-systolic pressure to a certain location at the medium with normal blood flow, so as to achieve a state of temporary blood flow cessation at the medium downstream of the certain location. When required, the control of the condition of the artificial kinetics can be further achieved by applying a perturbation of secondary pressure to the fleshy medium.
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Citations
36 Claims
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1. A non-invasive method for use in determining at least one desired characteristic of blood of a patient, the method comprising:
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(a) creating a condition of artificial blood kinetics at a measurement location in a patient'"'"'s blood perfused fleshy medium and maintaining this condition for a certain time period;
(b) applying an external electromagnetic field to the measurement location;
(c) detecting a time response of the medium from at least a portion of the measurement location to said external electromagnetic field; and
(d) generating measured data indicative of time evolutions of the response of the medium over at least a part of said certain time period;
wherein the response to said external electromagnetic field includes at least one of the following;
an acoustic response to illuminating incident light having a wavelength in a range where the scattering properties of blood are sensitive to light radiation, and an impedance of the portion of the medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A system for non-invasive determination of at least one desired characteristic of blood of a patient, the system comprising:
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(i) a pressurizing assembly arranged for creating a condition of artificial blood kinetics at a measurement location in a patient'"'"'s blood perfused fleshy medium and at least maintaining this condition for a certain time period;
(ii) a measuring probe including a source of an external electromagnetic field configured for applying said external electromagnetic field to said measurement location, and a detecting module configured for detecting a time response of the medium from at least a portion of the measurement location to said external electromagnetic field; and
(iii) a control unit electrically coupled to said pressurizing assembly, said control unit including;
a memory for storing reference data sensitive to patient individuality and indicative of the desired blood characteristic as a function of a characteristic parameter derived from said time response; and
a data acquisition and processing utility coupled to the detecting module for receiving and analyzing measured data therefrom and configured to utilize the reference data and determine said at least one desired blood characteristic. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification