METHOD OF OBTAINING IMMUNE CELLS FROM AN ANIMAL

• US 20050106129A1
• Filed: 06/24/2003
• Published: 05/19/2005
• Est. Priority Date: 05/11/2001
• Status: Active Grant

• Current Assignee: Ilya S. Koyfman, Joel I. Rosenblatt, Kevor S. Tenhuisen
• Original Assignee: Ilya S. Koyfman, Joel I. Rosenblatt, Kevor S. Tenhuisen
• Inventors: Rosenblatt, Joel, Koyfman, Ilya S., TenHuisen, Kevor S.
• Granted Patent: US 7,094,419 B2
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 2039/515 Animal cells
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.

Claims

1-40. -40. (canceled)

41. A method of obtaining immune cells from an animal comprising harvesting immune cells from an immune modulation device comprised of an impermeable biocompatible shell having an outer surface with plurality of pores of suitable size to allow the ingress and egress of immune cells and said impermeable biocompatible shell having an interior lumen, a biocompatible fibrous scaffolding being disposed within said interior lumen, said fibrous scaffolding comprising textured yarn containing crimped fibers having crimp points, wherein the orientation of filaments in said crimped fiber changes angle at said crimp points;

said interior lumen having therein a quantity of antigen or chemotatic agent sufficient to provoke an immune response that was implanted within an animal time sufficient to allow immune cells to migrate into the immune modulation device.

42. The method of claim 41 wherein the harvested cells are reintroduced to animals.

53. The method of claim 41 wherein said orientation of said crimped filaments at said crimp points changes angle by at least 10 degrees.

43-52. -52. (canceled)