Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
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Accused Products
Abstract
The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
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Citations
62 Claims
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1-27. -27. (canceled)
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28. A method of inducing analgesia in a subject, the method comprising administration of sufentanil to the subject at a therapeutically effective rate to provide substantially continuous delivery of sufentanil at about 10 μ
- g/hr over a period of at least 24 hours, wherein said administering induces analgesia in the subject.
- View Dependent Claims (29, 30, 31, 32, 33, 34)
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35. A method of inducing analgesia in a subject, the method comprising administration of sufentanil to the subject at a therapeutically effective rate to provide substantially continuous delivery of sufentanil at about 20 μ
- g/hr over a period of at least 24 hours, wherein said administering induces analgesia in the subject.
- View Dependent Claims (36, 37, 38, 39, 40, 41)
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42. A method of inducing analgesia in a subject, the method comprising administration of sufentanil to the subject at a therapeutically effective rate to provide substantially continuous delivery of sufentanil at about 30 μ
- g/hr over a period of at least 24 hours, wherein said administering induces analgesia in the subject.
- View Dependent Claims (43, 44, 45, 46, 47, 48)
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49. A method of inducing analgesia in a subject, the method comprising administration of sufentanil to the subject at a therapeutically effective rate to provide substantially continuous delivery of sufentanil at about 40 μ
- g/hr over a period of at least 24 hours, wherein said administering induces analgesia in the subject.
- View Dependent Claims (50, 51, 52, 53, 54, 55)
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56. A method of inducing analgesia in a subject, the method comprising administration of sufentanil to the subject at a therapeutically effective rate to provide substantially continuous delivery of sufentanil at about 50 μ
- g/hr over a period of at least 24 hours, wherein said administering induces analgesia in the subject.
- View Dependent Claims (57, 58, 59, 60, 61, 62)
Specification