Fabrication of drug loaded biodegradable polymer fibers
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Abstract
The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
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Citations
224 Claims
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1-198. -198. (canceled)
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199. A method of fabricating fibers, comprising:
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a) obtaining a water-in-oil type emulsion comprising an aqueous phase containing an active biomolecule in a biodegradable polymer solution, wherein said emulsion is stabilized by a surfactant; and
b) extruding said emulsion into a coagulating bath. - View Dependent Claims (200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211)
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212. A method of fabricating fibers with a linear gradient of bioactive molecules, said method comprising:
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a) obtaining a first polymer solution and a second polymer solution; and
b) mixing said first polymer solution and said second polymer solution in a continuously changing ratio to obtain a mixture of said first and second polymer solutions, while extruding said mixture into a coagulating bath. - View Dependent Claims (213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 224)
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223. The method of claim 253, wherein the coagulating bath solvent further comprises a polymer solvent.
Specification