Metallic structures incorporating bioactive materials and methods for creating the same

• US 20050106212A1
• Filed: 11/27/2002
• Published: 05/19/2005
• Est. Priority Date: 09/19/2001
• Status: Abandoned Application

• Current Assignee: Medlogics Device Corporation
• Original Assignee: Medlogics Device Corporation
• Inventors: Schlesinger, Mordachay, Gertner, Michael E.
• Application Number:
  US10/497,198
• Publication Number:
  US 20050106212A1
• Time in Patent Office: Days
• US Class Current: 424/425
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/434 of enzymes
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/42 having an inorganic matrix
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/082 Inorganic materials
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/121 having an inorganic matrix
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 : Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C23C 18/165 : Multilayered product layered product B32B
• CPC Class Codes: C23C 18/1657 : Electroless forming, i.e. substrate removed or destroyed at the end of the process
• CPC Class Codes: C23C 18/1662 : Use of incorporated material in the solution or dispersion, e.g. particles, whiskers, wires
• CPC Class Codes: C23C 18/1831 : Use of metal, e.g. activation, sensitisation with noble metals
• CPC Class Codes: C25D 15/00 : Electrolytic or electrophoretic production of coatings containing embedded materials, e.g. particles, whiskers, wires
• CPC Class Codes: C25D 5/022 : using masking means
• CPC Class Codes: C25D 5/48 : After-treatment of electroplated surfaces
• CPC Class Codes: C25D 5/617 : Crystalline layers
• CPC Class Codes: C25D 5/619 : Amorphous layers
• CPC Class Codes: C25D 5/623 : Porosity of the layers

Abstract

One embodiment of the invention is directed to a method comprising providing an electrochemical solution comprising metal ions and a bioactive material such as bioactive molecules, and then contacting the electrochemical solution and a substrate. A bioactive composite structure is formed on the substrate using an electrochemical process, where the bioactive composite structure includes a metal matrix and the bioactive material within the metal matrix.

Claims

1. A method comprising:

(a) providing an electrochemical solution comprising metal ions and a bioactive material;

(b) contacting the electrochemical solution and a substrate; and

(c) forming a bioactive composite structure on the substrate using an electrochemical process, wherein the bioactive composite structure includes a metal matrix and the bioactive material within the metal matrix.

2. The method of claim 1 wherein the metal ions in the electro chemical solution are derived from metal salts, and wherein the electrochemical solution further comprises a reducing agent.

3. The method of claim 1 wherein the electrochemical process is an electroless deposition process.

4. The method of claim 1 wherein the bioactive composite structure is in the form of a layer on the substrate.

5. The method of claim 1 wherein the substrate is a sacrificial substrate, and wherein the method further includes:

(d) removing the sacrificial substrate from the bioactive composite structure.

6. The method of claim 5 wherein the substrate and the bioactive composite structure form a coated stent.

7. The method of claim 1 wherein the bioactive material comprises a drug.

8. The method of claim 1 wherein the matrix comprises nickel, chromium, gold, silver, copper, cobalt, or alloyed combinations thereof.

9. The method of claim 1 wherein the electrochemical process is an electrolytic deposition process.

10. The method of claim 1 further comprising:

forming a topcoat on the bioactive composite structure.

11. The method of claim 10 wherein the topcoat comprises a metal.

12. The method of claim 10 wherein the topcoat comprises a polymeric material.

13. The method of claim 10 wherein the topcoat comprises a self-assembled monolayer.

14. A bioactive composite structure comprising:

(a) a metal matrix, wherein the metal matrix is formed using an electrochemical process; and

(b) a bioactive material within the metal matrix.

15. The bioactive composite structure of claim 14 wherein the bioactive composite structure forms a stent.

16. The bioactive composite structure of claim 14 wherein the bioactive composite structure is in the form of a layer on a stent.

17. The bioactive composite structure of claim 14 wherein the bioactive material comprises drugs.

18. The bioactive composite structure of claim 14 wherein the metal matrix comprises a metal alloy.

19. The bioactive composite structure of claim 14 wherein an average void size of the metal matrix is less than about 100 angstroms.

20. The bioactive composite structure of claim 14 wherein the bioactive composite structure is in the form of a layer.

21-124. -124. (canceled)