Pretreatment method and system for enhancing transdermal drug delivery
First Claim
1. A drug delivery system for delivering a biologically active agent through the skin of a patient, comprising:
- a pretreatment patch adapted to be placed on the patient'"'"'s skin, said pretreatment patch having a backing membrane ring and a microprojection array, said microprojection array being adhered to said backing membrane ring, said microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, said pretreatment patch including a release liner ring that is removably secured to said backing membrane and a skin adhesive ring that is adhered to said release liner ring, said release liner ring and said skin adhesive ring being adapted to form a skin template on the patient'"'"'s skin after said pretreatment patch is applied to and removed from the patient'"'"'s skin; and
a gel patch having a top and bottom surface, said gel patch including a reservoir containing a hydrogel formulation, said gel patch having a skin contact area in the range of approximately 0.5-30 cm2, said gel patch being adapted to be disposed on said skin template.
1 Assignment
0 Petitions
Accused Products
Abstract
A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient'"'"'s skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient'"'"'s skin after the pretreatment patch is applied to and removed from the patient'"'"'s skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.
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Citations
63 Claims
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1. A drug delivery system for delivering a biologically active agent through the skin of a patient, comprising:
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a pretreatment patch adapted to be placed on the patient'"'"'s skin, said pretreatment patch having a backing membrane ring and a microprojection array, said microprojection array being adhered to said backing membrane ring, said microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, said pretreatment patch including a release liner ring that is removably secured to said backing membrane and a skin adhesive ring that is adhered to said release liner ring, said release liner ring and said skin adhesive ring being adapted to form a skin template on the patient'"'"'s skin after said pretreatment patch is applied to and removed from the patient'"'"'s skin; and
a gel patch having a top and bottom surface, said gel patch including a reservoir containing a hydrogel formulation, said gel patch having a skin contact area in the range of approximately 0.5-30 cm2, said gel patch being adapted to be disposed on said skin template. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A pretreatment device for pre-treating a patient'"'"'s skin, comprising:
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a backing membrane ring; and
a microprojection array, said microprojection array being adhered to said backing membrane ring, said microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, said pretreatment patch including a release liner ring that is removably secured to said backing membrane and a skin adhesive ring that is adhered to said release liner ring, said release liner ring and said skin adhesive ring being adapted to form a skin template on the patient'"'"'s skin after said pretreatment patch is applied to and removed from the patient'"'"'s skin. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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35. A method for delivering a biologically active agent through the skin of a patient, comprising the steps of:
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providing a pretreatment patch adapted to be placed on the patient'"'"'s skin, said pretreatment patch having a backing membrane ring and a microprojection array, said microprojection array being adhered to said backing membrane ring, said microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, said pretreatment patch including a release liner ring that is removably secured to said backing membrane and a skin adhesive ring that is adhered to said release liner ring, said release liner ring and said skin adhesive ring being adapted to form a skin template on the patient'"'"'s skin after said pretreatment patch is applied to and removed from the patient'"'"'s skin;
providing a gel patch having a top and bottom surface, said gel patch including a reservoir containing a hydrogel formulation, said gel patch having a skin contact area in the range of approximately 0.5-30 cm2;
applying said pretreatment patch to the patient'"'"'s skin, whereby said microprojections pierce said stratum corneum of the patient to provide a pretreated skin area having a plurality of microslits and whereby said skin template adheres to the patient'"'"'s skin;
removing said pretreatment patch from the patient'"'"'s skin; and
applying said gel patch to said pretreated skin area, said gel patch being positioned over said skin template, whereby said hydrogel formulation is released from said reservoir and migrates into and through said microslits formed in said stratum corneum by said pretreatment patch. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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Specification