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Pretreatment method and system for enhancing transdermal drug delivery

  • US 20050106226A1
  • Filed: 10/21/2004
  • Published: 05/19/2005
  • Est. Priority Date: 10/24/2003
  • Status: Abandoned Application
First Claim
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1. A drug delivery system for delivering a biologically active agent through the skin of a patient, comprising:

  • a pretreatment patch adapted to be placed on the patient'"'"'s skin, said pretreatment patch having a backing membrane ring and a microprojection array, said microprojection array being adhered to said backing membrane ring, said microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, said pretreatment patch including a release liner ring that is removably secured to said backing membrane and a skin adhesive ring that is adhered to said release liner ring, said release liner ring and said skin adhesive ring being adapted to form a skin template on the patient'"'"'s skin after said pretreatment patch is applied to and removed from the patient'"'"'s skin; and

    a gel patch having a top and bottom surface, said gel patch including a reservoir containing a hydrogel formulation, said gel patch having a skin contact area in the range of approximately 0.5-30 cm2, said gel patch being adapted to be disposed on said skin template.

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