Bioarray chip reaction apparatus and its manufacture
First Claim
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1. A method of making probe chips comprising the steps of:
- forming a plurality of probe arrays on a wafer;
separating said wafer into a plurality of chips, each of said chips comprising at least one probe array thereon; and
mating at least one of said chips to a package, said package comprising a reaction chamber, said reaction chamber comprising inlets for flowing fluid therein, said at least one probe array in fluid communication with said reaction chamber.
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Abstract
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
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Citations
129 Claims
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1. A method of making probe chips comprising the steps of:
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forming a plurality of probe arrays on a wafer;
separating said wafer into a plurality of chips, each of said chips comprising at least one probe array thereon; and
mating at least one of said chips to a package, said package comprising a reaction chamber, said reaction chamber comprising inlets for flowing fluid therein, said at least one probe array in fluid communication with said reaction chamber.
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2-92. -92. (canceled)
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93. An array assay device, said device comprising:
- (a) a substrate receiving element for receiving a substrate having at least on array thereon, said substrate receiving element comprising a bottom surface; and
(b) a compression element for urging said bottom surface in a direction towards a substrate when present in said substrate receiving element so as to hold said bottom surface in a fixed position relative to said substrate. - View Dependent Claims (94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129)
- (a) a substrate receiving element for receiving a substrate having at least on array thereon, said substrate receiving element comprising a bottom surface; and
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108. A method for performing an array assay, said method comprising:
- (a) providing an array assay device comprising;
(i) a bottom surface, (ii) a substrate receiving element for receiving a substrate having at least on array thereon, and (iii) a compression element for urging said bottom surface in a direction towards a substrate when present in said substrate receiving element so as to hold said bottom surface in a fixed position relative to said substrate;
(b) positioning a substrate comprising at least one array in said substrate receiving element;
(c) urging said bottom surface in a direction towards said positioned substrate using said compression element, whereby said bottom surface is fixed relative to said substrate present in said receiving element; and
(e) contacting a sample to said at least one array. - View Dependent Claims (109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119)
- (a) providing an array assay device comprising;
Specification