Sample element for use in material analysis
First Claim
Patent Images
1. A method for determining a concentration of an analyte in a material sample, said method comprising:
- providing a sample element comprising a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorptivity of electromagnetic radiation incident thereon; and
employing said sample element with an analyte detection system which determines the concentration of said analyte with clinically acceptable accuracy.
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Abstract
A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The method further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.
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Citations
67 Claims
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1. A method for determining a concentration of an analyte in a material sample, said method comprising:
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providing a sample element comprising a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorptivity of electromagnetic radiation incident thereon; and
employing said sample element with an analyte detection system which determines the concentration of said analyte with clinically acceptable accuracy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for estimating a concentration of an analyte in a material sample, said method comprising:
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providing a sample element comprising a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon; and
employing said sample element with an analyte detection system which computes an estimated concentration of said analyte in said material sample, over a series of more than about 30 measurements, with a standard error of less than about 50 mg/dL at 95% confidence level, when compared to the actual concentration of said analyte. - View Dependent Claims (14, 15, 16)
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17. A method for estimating a concentration of an analyte in a material sample, said method comprising:
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providing a sample element comprising a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon; and
employing said sample element with an analyte detection system which computes an estimated concentration of said analyte in said material sample;
said estimated concentration differing, over a series of more than about 30 measurements, from the actual concentration of said analyte with a root-mean-squared error of less than about 70 mg/dl. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A system for estimating the concentration of an analyte in a material sample, said system comprising:
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a source of infrared radiation;
a detector positioned to detect infrared radiation emitted by the source, so that said source and said detector define an optical path therebetween;
a processor coupled to said detector; and
a sample element positioned within said optical path, said sample element comprising;
a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon, wherein said material sample is positionable in said sample chamber and said sample chamber is positionable in said optical path, and wherein said processor calculates an estimated concentration of said analyte in said material sample in response to signals from said detector, said estimated concentration differing, over a series of more than about 30 measurements, from the actual concentration of said analyte with a root-mean-squared error of less than about 70 mg/dl. - View Dependent Claims (25, 26, 27)
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28. A system for determining the concentration of an analyte in a material sample, said system comprising:
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a source of infrared radiation;
a detector positioned to detect infrared radiation emitted by the source, so that said source and said detector define an optical path therebetween; and
a sample element positioned within said optical path, said sample element comprising;
a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon, wherein said material sample is positionable in said sample chamber and said sample chamber is positionable in said optical path, and wherein said system determines the concentration of said analyte with clinically acceptable accuracy. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35)
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36. A sample element for use in measuring the concentration of an analyte in a material sample, said element comprising:
a sample chamber at least partially defined by at least one window, said at least one window having greater than about 1% wavelength-domain variation in absorbance of electromagnetic radiation incident thereon. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A sample element for use in measuring the concentration of an analyte in a material sample, said sample element comprising:
a sample chamber at least partially defined by at least one window, said at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A sample element for use in determining a concentration of an analyte in a material sample, said sample element comprising:
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a sample chamber at least partially defined by at least one window, said at least one window having greater than about 1% wavelength-domain variation in absorbance of electromagnetic radiation incident thereon;
said sample chamber having an associated first optical pathlength in a first configuration and a second optical pathlength in a second configuration. - View Dependent Claims (62)
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63. A sample element adapted to hold a sample in an optical path of a light beam for multiple optical transmission measurements to determine an analyte concentration of the sample, the sample element comprising:
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a sample chamber adapted to contain the sample and having a chamber thickness;
at least one wall portion which at least partially defines the sample chamber, the wall portion having a wall thickness; and
an optical pathlength comprising the chamber thickness and the wall thickness, whereby the optical pathlength is adapted to be modified between subsequent optical transmission measurements. - View Dependent Claims (64, 65, 66, 67)
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Specification