Processes for preparing novel methylene blue derivative
First Claim
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1. A method for synthesizing [7-(dipropylamino)phenothiazin-3-ylidene]dipropylamine comprising the steps of:
- (a) reacting phenothiazine with dipropyl amine in the presence of bromine;
(b) purifying the product of step (a).
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Abstract
Methods for the preparation of 7-(dipropylamino)pheno-thiazin-3-ylidene]-dipropylamine
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Citations
7 Claims
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1. A method for synthesizing [7-(dipropylamino)phenothiazin-3-ylidene]dipropylamine comprising the steps of:
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(a) reacting phenothiazine with dipropyl amine in the presence of bromine;
(b) purifying the product of step (a).
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2. A method of the synthesis of [7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine comprising the step of reacting 3,7-dibromophenothiazine-5-ium bromide with dipropyl amine optionally in the presence of Copper.
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3. A method for the synthesis of [7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine comprising the steps of:
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(a) acetylating the ring nitrogen of 3,7-dinitrophenothiazine;
(b) reducing the product of step (a);
(c) alkylating the product of step (b) with;
(c′
) propyl bromide and a base or (c″
) propyl aldehyde plus NaBH3CN.
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4. A method for isolating 7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine from an impure mixture comprising the steps of:
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(a) dissolving the impure mixture in hot water;
(b) filtering the hot solution of step (a) to remove insoluble matters;
(c) treating the hot filtrate of step (b) with ZnCl2 to precipatate the ZnCl2 salt;
(d) dissolving the ZnCl2 salt in a base;
(e) washing the filtrate of step (d) with an organic solvent treating the same with a salt to precipitate 7-(dipropylamino)pheno-thiazin-3-ylidene]-dipropylamine.
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5. A method for preparing 7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine comprising the step of reacting (4-aminophenyl)dipropylamine with [2-amino-5-(dipropylamino)phenyl]-thiosulfonic acid.
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6. A method for preparing 7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine comprising the step of reacting reacting (4-{[4-(dipropylamino)phenyl]amino}phenyl)-dipropylamine with S, I2, DCB.
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7. A method of the synthesis of [7-(dipropylamino)pheno-thiazin-3-ylidene]dipropylamine comprising the step of reacting phenothiazine or any salt thereof with dipropyl amine optionally in the presence of Copper.
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