Occludable intravascular catheter for drug delivery and method of using the same

• US 20050107738A1
• Filed: 08/19/2004
• Published: 05/19/2005
• Est. Priority Date: 07/21/2000
• Status: Abandoned Application

• Current Assignee: Veinrx Inc.
• Original Assignee: Veinrx Inc.
• Inventors: Jahrmarkt, Scott L., Slater, Charles R., Lary, Banning G., Bales, Thomas O., Naglreiter, Brett E.
• Application Number:
  US10/922,221
• Publication Number:
  US 20050107738A1
• Time in Patent Office: Days
• US Class Current: 604/96.10
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0008 having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0166 Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 2025/1015 having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/0029 characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports catheter shaft surface irregularities A61M2025/006
• CPC Class Codes: A61M 25/0032 characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 25/0097 characterised by the hub connectors A61M39/10
• CPC Class Codes: A61M 25/0127 Magnetic means; Magnetic markers
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Methods and apparatus for treating the interior of a blood vessel include a variety of catheter designs, methods and apparatus for occluding a blood vessel, methods and apparatus for locating an occlusion device, methods and apparatus for locating a treating device at the site of blood vessel tributaries, and methods and apparatus for dispensing treating agent.

Claims

1. A device for treating blood vessels, comprising:

an elongate body having a proximal end, a distal end, and an infusion lumen extending there through;

a plurality of elution holes, in valved communication with the infusion lumen; and

a wall which is movable between a first position in which the wall blocks communication between the infusion lumen and the elution holes, and a second position in which the infusion lumen is in communication with the elution holes.

2. The device of claim 1, wherein the wall is movable in response to a change in pressure.

3. The device of claim 1, wherein the wall is movable in response to introduction of an inflation media.

4. The device of claim 1, wherein the wall is in the form of an inflatable tube.

5. The device of claim 4, further comprising a side lumen on the body, and wherein the inflatable tube is positioned within the side lumen.

6. The device of claim 4, wherein the tube is positioned within the infusion lumen.

7. The device of claim 4, wherein the inflatable tube has an axial length of at least about 0.5 cm.

8. The device of claim 1, wherein the total fluid resistance of the elution holes is about equal to or greater than the total fluid resistance of the infusion lumen.

9. The device of claim 1, wherein the total fluid resistance of the elution holes is at least about 125% of the fluid resistance of the infusion lumen.

10. The device of claim 1, wherein the average hydraulic diameter of the elution holes is less than about 0.010″

.

11. The device of claim 1, wherein the average hydraulic diameter of the elution holes is less than about 0.004″

.

12. The device of claim 1, wherein the average spacing between elution holes is within the range of from about 1 cm to about 2 cm.

13. The device of claim 1, further comprising an inflatable occlusion balloon carried by the distal end of the body.

14. The device of claim 1, further comprising a guidewire lumen extending axially through at least a portion of the length of the elongate body.

15. The device of claim 5, wherein the inflatable tube has a deflated diameter, the side lumen has an inside diameter, and the deflated diameter is no more than about 75% of the inside diameter.

16. A fluid delivery catheter, comprising:

an elongate, flexible tubular body, having a proximal end and a distal end;

an infusion lumen extending through the body from the proximal end in the direction of the distal end;

at least two infusion ports on the tubular body; and

an inflatable tube within the tubular body;

wherein at least one infusion port is in communication with the infusion lumen when the inflatable tube is in a first inflation state, and the infusion port is isolated from the infusion lumen when the inflatable tube is in a second inflation state.

17. A fluid delivery catheter as in claim 16, further comprising a vascular occlusion balloon on the distal end of the tubular body.

18. A fluid delivery catheter as in claim 17, further comprising a proximal manifold having an infusion port in communication with the infusion lumen, and an inflation port in communication with the occlusion balloon.

19. A method of treating a body lumen, comprising:

providing a catheter with an infusion lumen and a plurality of elution holes in selective communication with the infusion lumen, the catheter having a first configuration adapted to resist flow through at least one elution hole and a second configuration adapted to allow flow through the at least one elution hole;

inserting the catheter into a patient;

introducing a therapeutic fluid into the infusion lumen; and

changing the catheter from the first configuration to the second configuration to permit escape of therapeutic fluid through the at least one elution hole.

20. A method of treating a body lumen as in claim 19, wherein the changing the catheter step comprising moving a movable wall from a first position in which communication between the at least one elution hole and the infusion lumen is interrupted, to a second position in which the at least one elution hole is in communication with the infusion lumen.

21. A method of treating a body lumen as in claim 20, wherein the changing the catheter step comprises deflating a tubular flow regulator.

22. A method of introducing a therapeutic agent into a vein, comprising the steps of:

introducing a catheter into the vein, the catheter having a plurality of infusion ports and an infusion lumen;

activating an occlusion device on the catheter to occlude blood flow within the vein;

removing a barrier from at least one of the plurality of infusion ports; and

infusing therapeutic agent from the infusion lumen, through the ports and into the vein.

23. A method of introducing a therapeutic agent into a vein as in claim 22, wherein the introducing step comprises introducing the catheter into the saphenous vein.

24. A method of introducing a therapeutic agent into a vein as in claim 23, wherein the introducing step comprises introducing the catheter into the saphenous vein in the vicinity of the knee.

25. A method of introducing a therapeutic agent into a vein as in claim 23, wherein the introducing step comprises introducing the catheter into the saphenous vein in the vicinity of the ankle.

26. A method of introducing a therapeutic agent into a vein as in claim 22, wherein the activating an occlusion device step comprises inflating an occlusion balloon.

27. A method of introducing a therapeutic agent into a vein as in claim 22, wherein the activating an occlusion device step is accomplished to isolate the saphenofemoral junction from the infusion ports.

28. A method of introducing a therapeutic agent into a vein as in claim 22, wherein the removing a barrier step comprises deflating an elongate, tubular bladder.

29. A method of introducing a therapeutic agent into a vein as in claim 22, further comprising enhancing drainage of the vein by raising the position of the vein relative to the location of the occlusion device.

30. A method of introducing a therapeutic agent into a vein as in claim 22, further comprising lowering the position of the vein relative to the location of the occlusion device to facilitate migration of therapeutic agent along the vein;

wherein the therapeutic agent is a foam.

31. A method of introducing a therapeutic agent into a vein as in claim 22, further comprising maintaining a raised position of the vein relative to the location of the occlusion device to facilitate migration of the therapeutic agent to the saphenofemoral junction.

32. A method of inhibiting retrograde flow of body fluid through the effluent ports and into the infusion lumen of a catheter, comprising the steps of:

providing a fluid delivery catheter, having an elongate body, at least one effluent port on the body and an infusion lumen extending within the body;

inflating a flow regulator within the tubular body to isolate the effluent port from the infusion lumen; and

introducing the catheter into a patient in a location that exposes the catheter to a body fluid;

wherein the flow regulator inhibits retrograde flow of body fluid through the effluent port and into the infusion lumen.

33. A method of inhibiting retrograde flow of body fluid as in claim 32, wherein the inflating a flow regulator step comprises inflating an elongate tubular balloon.

34. A method of inhibiting retrograde flow of body fluid as in claim 32, additionally comprising the step of deflating the flow regulator to place the effluent port in communication with the infusion lumen.