Targeted cooling of tissue within a body
First Claim
1. A method of cooling a target tissue region inside a body, the method comprising:
- providing fluid cooled below normal body temperature and blood at a normal body temperature to the tissue region in proportions to cool the tissue region and maintain, for an extended period of time, the temperature of the tissue region within a target temperature range that is below normal body temperature.
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Accused Products
Abstract
Devices and methods to cool a target tissue region inside the body are described. Fluid cooled below normal body temperature and blood at a normal body temperature are provided to the tissue region in proportions to cool the tissue region. A system for controlling the temperature of the target tissue region is disclosed. The system includes a catheter and a control system that controls the amount of cool fluid and blood provided to the tissue region. A catheter for providing cool fluid to the tissue region is also provided. The catheter includes a temperature sensor that extends to a location distal to the distal end of the catheter to sense the temperature of the tissue region.
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Citations
40 Claims
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1. A method of cooling a target tissue region inside a body, the method comprising:
providing fluid cooled below normal body temperature and blood at a normal body temperature to the tissue region in proportions to cool the tissue region and maintain, for an extended period of time, the temperature of the tissue region within a target temperature range that is below normal body temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of cooling a target tissue region inside a body, the method comprising:
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occluding a body vessel to prevent normal blood flow to the tissue region;
providing, while the body vessel is occluded, cooled fluid to the tissue region to cool the tissue region below normal body temperature;
recommencing normal blood flow to the tissue region by removing the occlusion in the body vessel;
preventing normal blood flow to the tissue region again by occluding the body vessel before the temperature of the tissue region returns to normal body temperature; and
providing, while the body vessel is occluded, cooled fluid to the tissue region again to maintain the temperature of the tissue region below normal body temperature. - View Dependent Claims (15, 16, 17)
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18. A method of cooling a target tissue region inside a body, the method comprising:
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restricting normal blood flow to the tissue region so that only a desired amount of blood is provided to the tissue region; and
providing cool fluid to mix with the blood provided to the tissue region so as to cool the tissue region below normal body temperature and to maintain, for an extended period of time, the temperature of the tissue region within a target tissue range that is below normal body temperature. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
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26. A system for controlling the temperature of a target tissue region inside the body, the system comprising:
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a catheter for providing cooled fluid to the tissue region and for controlling normal blood flow to the tissue region; and
a control system that controls the amount of the cooled fluid and blood that the catheter provides to the tissue region so as to cool and to maintain, for an extended period of time, the tissue region within a target temperature range that is below normal body temperature. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A catheter for providing cool fluid to a tissue region inside a body, the catheter comprising:
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an elongated member having a lumen extending longitudinally therethrough to a distal end of the elongated member; and
a temperature sensor that extends to a location distal to the distal end of the elongated member to sense the temperature of the tissue region. - View Dependent Claims (37, 38, 39, 40)
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Specification